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Gene: CCDC137 |
Gene summary for CCDC137 |
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Gene information | Species | Human | Gene symbol | CCDC137 | Gene ID | 339230 |
Gene name | coiled-coil domain containing 137 | |
Gene Alias | RaRF | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001650 | UniProtAcc | Q6PK04 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339230 | CCDC137 | LZE2T | Human | Esophagus | ESCC | 7.08e-06 | 5.01e-01 | 0.082 |
339230 | CCDC137 | LZE4T | Human | Esophagus | ESCC | 1.61e-10 | 3.71e-01 | 0.0811 |
339230 | CCDC137 | LZE7T | Human | Esophagus | ESCC | 9.48e-13 | 5.85e-01 | 0.0667 |
339230 | CCDC137 | LZE8T | Human | Esophagus | ESCC | 1.04e-07 | 2.25e-01 | 0.067 |
339230 | CCDC137 | LZE20T | Human | Esophagus | ESCC | 4.36e-08 | 2.71e-01 | 0.0662 |
339230 | CCDC137 | LZE22T | Human | Esophagus | ESCC | 7.64e-05 | 3.80e-01 | 0.068 |
339230 | CCDC137 | LZE24T | Human | Esophagus | ESCC | 1.05e-16 | 4.79e-01 | 0.0596 |
339230 | CCDC137 | LZE21T | Human | Esophagus | ESCC | 1.04e-04 | 4.28e-01 | 0.0655 |
339230 | CCDC137 | P1T-E | Human | Esophagus | ESCC | 1.21e-12 | 7.02e-01 | 0.0875 |
339230 | CCDC137 | P2T-E | Human | Esophagus | ESCC | 1.94e-20 | 4.68e-01 | 0.1177 |
339230 | CCDC137 | P4T-E | Human | Esophagus | ESCC | 9.58e-14 | 4.89e-01 | 0.1323 |
339230 | CCDC137 | P5T-E | Human | Esophagus | ESCC | 5.93e-25 | 6.13e-01 | 0.1327 |
339230 | CCDC137 | P8T-E | Human | Esophagus | ESCC | 3.92e-18 | 3.86e-01 | 0.0889 |
339230 | CCDC137 | P9T-E | Human | Esophagus | ESCC | 8.10e-11 | 3.30e-01 | 0.1131 |
339230 | CCDC137 | P10T-E | Human | Esophagus | ESCC | 6.88e-27 | 5.49e-01 | 0.116 |
339230 | CCDC137 | P11T-E | Human | Esophagus | ESCC | 2.31e-20 | 9.13e-01 | 0.1426 |
339230 | CCDC137 | P12T-E | Human | Esophagus | ESCC | 2.05e-27 | 4.89e-01 | 0.1122 |
339230 | CCDC137 | P15T-E | Human | Esophagus | ESCC | 5.69e-20 | 5.56e-01 | 0.1149 |
339230 | CCDC137 | P16T-E | Human | Esophagus | ESCC | 3.61e-20 | 3.62e-01 | 0.1153 |
339230 | CCDC137 | P17T-E | Human | Esophagus | ESCC | 6.19e-05 | 4.74e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC137 | SNV | Missense_Mutation | rs375426067 | c.791N>T | p.Ala264Val | p.A264V | Q6PK04 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | c.186G>C | p.Glu62Asp | p.E62D | Q6PK04 | protein_coding | deleterious(0.03) | probably_damaging(0.96) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC137 | SNV | Missense_Mutation | c.784N>C | p.Tyr262His | p.Y262H | Q6PK04 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CCDC137 | insertion | Frame_Shift_Ins | novel | c.229_230insGCAGCATCGCCCGCGGACGGGATCCGGCAACCCC | p.Met77SerfsTer18 | p.M77Sfs*18 | Q6PK04 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
CCDC137 | SNV | Missense_Mutation | rs371084134 | c.685N>T | p.Arg229Trp | p.R229W | Q6PK04 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AY-5543-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.178N>A | p.Glu60Lys | p.E60K | Q6PK04 | protein_coding | deleterious(0.01) | benign(0.193) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC137 | SNV | Missense_Mutation | novel | c.338N>C | p.Lys113Thr | p.K113T | Q6PK04 | protein_coding | deleterious(0.01) | possibly_damaging(0.663) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC137 | SNV | Missense_Mutation | novel | c.235N>G | p.Asn79Asp | p.N79D | Q6PK04 | protein_coding | tolerated(0.2) | benign(0.033) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.242T>G | p.Ile81Ser | p.I81S | Q6PK04 | protein_coding | tolerated(0.76) | benign(0.058) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.141G>T | p.Glu47Asp | p.E47D | Q6PK04 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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