GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457858 | Lung | IAC | positive regulation of cell adhesion | 87/2061 | 437/18723 | 2.59e-08 | 3.13e-06 | 87 |
GO:00072495 | Lung | IAC | I-kappaB kinase/NF-kappaB signaling | 56/2061 | 281/18723 | 7.39e-06 | 2.62e-04 | 56 |
GO:00431226 | Lung | IAC | regulation of I-kappaB kinase/NF-kappaB signaling | 51/2061 | 249/18723 | 8.41e-06 | 2.87e-04 | 51 |
GO:00488728 | Lung | IAC | homeostasis of number of cells | 54/2061 | 272/18723 | 1.20e-05 | 3.64e-04 | 54 |
GO:00510903 | Lung | IAC | regulation of DNA-binding transcription factor activity | 76/2061 | 440/18723 | 4.44e-05 | 1.05e-03 | 76 |
GO:00510914 | Lung | IAC | positive regulation of DNA-binding transcription factor activity | 50/2061 | 260/18723 | 5.87e-05 | 1.29e-03 | 50 |
GO:00224078 | Lung | IAC | regulation of cell-cell adhesion | 76/2061 | 448/18723 | 8.16e-05 | 1.68e-03 | 76 |
GO:00431235 | Lung | IAC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 38/2061 | 186/18723 | 1.19e-04 | 2.25e-03 | 38 |
GO:0051092 | Lung | IAC | positive regulation of NF-kappaB transcription factor activity | 32/2061 | 152/18723 | 2.25e-04 | 3.90e-03 | 32 |
GO:00421106 | Lung | IAC | T cell activation | 77/2061 | 487/18723 | 6.82e-04 | 9.20e-03 | 77 |
GO:00091508 | Lung | IAC | purine ribonucleotide metabolic process | 61/2061 | 368/18723 | 7.24e-04 | 9.60e-03 | 61 |
GO:00725218 | Lung | IAC | purine-containing compound metabolic process | 67/2061 | 416/18723 | 9.03e-04 | 1.11e-02 | 67 |
GO:00224097 | Lung | IAC | positive regulation of cell-cell adhesion | 49/2061 | 284/18723 | 9.60e-04 | 1.16e-02 | 49 |
GO:00092597 | Lung | IAC | ribonucleotide metabolic process | 62/2061 | 385/18723 | 1.38e-03 | 1.53e-02 | 62 |
GO:00071596 | Lung | IAC | leukocyte cell-cell adhesion | 60/2061 | 371/18723 | 1.47e-03 | 1.57e-02 | 60 |
GO:00061638 | Lung | IAC | purine nucleotide metabolic process | 63/2061 | 396/18723 | 1.72e-03 | 1.78e-02 | 63 |
GO:0050852 | Lung | IAC | T cell receptor signaling pathway | 25/2061 | 123/18723 | 1.75e-03 | 1.80e-02 | 25 |
GO:00508636 | Lung | IAC | regulation of T cell activation | 54/2061 | 329/18723 | 1.77e-03 | 1.82e-02 | 54 |
GO:19031311 | Lung | IAC | mononuclear cell differentiation | 66/2061 | 426/18723 | 2.63e-03 | 2.44e-02 | 66 |
GO:00196937 | Lung | IAC | ribose phosphate metabolic process | 62/2061 | 396/18723 | 2.72e-03 | 2.49e-02 | 62 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CARD11 | SNV | Missense_Mutation | novel | c.3017N>T | p.Ser1006Leu | p.S1006L | Q9BXL7 | protein_coding | deleterious(0.01) | benign(0.021) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
CARD11 | SNV | Missense_Mutation | | c.2470N>C | p.Asp824His | p.D824H | Q9BXL7 | protein_coding | tolerated(0.19) | benign(0.149) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CARD11 | SNV | Missense_Mutation | novel | c.2020N>A | p.Asp674Asn | p.D674N | Q9BXL7 | protein_coding | deleterious(0.02) | benign(0.157) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD11 | SNV | Missense_Mutation | novel | c.466N>G | p.Leu156Val | p.L156V | Q9BXL7 | protein_coding | tolerated(0.45) | benign(0.01) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD11 | SNV | Missense_Mutation | | c.2159N>A | p.Arg720Gln | p.R720Q | Q9BXL7 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-AR-A2LH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
CARD11 | SNV | Missense_Mutation | | c.41N>T | p.Thr14Met | p.T14M | Q9BXL7 | protein_coding | deleterious_low_confidence(0.04) | benign(0.125) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
CARD11 | SNV | Missense_Mutation | rs372251654 | c.3382G>A | p.Val1128Ile | p.V1128I | Q9BXL7 | protein_coding | tolerated(0.42) | benign(0.001) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CARD11 | SNV | Missense_Mutation | | c.930G>C | p.Lys310Asn | p.K310N | Q9BXL7 | protein_coding | deleterious(0.01) | benign(0.075) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
CARD11 | SNV | Missense_Mutation | | c.2823N>C | p.Leu941Phe | p.L941F | Q9BXL7 | protein_coding | tolerated(0.21) | benign(0) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
CARD11 | SNV | Missense_Mutation | | c.625G>A | p.Ala209Thr | p.A209T | Q9BXL7 | protein_coding | deleterious(0) | benign(0.312) | TCGA-OL-A66N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |