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Gene: C6orf47 |
Gene summary for C6ORF47 |
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Gene information | Species | Human | Gene symbol | C6orf47 | Gene ID | 57827 |
Gene name | chromosome 6 open reading frame 47 | |
Gene Alias | D6S53E | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A1U9X7F2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57827 | C6orf47 | LZE4T | Human | Esophagus | ESCC | 1.27e-03 | 1.63e-01 | 0.0811 |
57827 | C6orf47 | LZE5T | Human | Esophagus | ESCC | 1.75e-02 | 2.02e-01 | 0.0514 |
57827 | C6orf47 | LZE20T | Human | Esophagus | ESCC | 2.64e-05 | 2.01e-01 | 0.0662 |
57827 | C6orf47 | LZE24T | Human | Esophagus | ESCC | 3.38e-15 | 5.33e-01 | 0.0596 |
57827 | C6orf47 | P1T-E | Human | Esophagus | ESCC | 3.72e-03 | 2.98e-01 | 0.0875 |
57827 | C6orf47 | P2T-E | Human | Esophagus | ESCC | 9.89e-21 | 4.55e-01 | 0.1177 |
57827 | C6orf47 | P4T-E | Human | Esophagus | ESCC | 6.05e-16 | 4.21e-01 | 0.1323 |
57827 | C6orf47 | P5T-E | Human | Esophagus | ESCC | 5.95e-17 | 1.06e-01 | 0.1327 |
57827 | C6orf47 | P8T-E | Human | Esophagus | ESCC | 8.96e-12 | 2.05e-01 | 0.0889 |
57827 | C6orf47 | P9T-E | Human | Esophagus | ESCC | 1.12e-10 | 2.77e-01 | 0.1131 |
57827 | C6orf47 | P10T-E | Human | Esophagus | ESCC | 7.40e-15 | 1.83e-01 | 0.116 |
57827 | C6orf47 | P11T-E | Human | Esophagus | ESCC | 4.11e-09 | 4.16e-01 | 0.1426 |
57827 | C6orf47 | P12T-E | Human | Esophagus | ESCC | 5.27e-15 | 2.97e-01 | 0.1122 |
57827 | C6orf47 | P15T-E | Human | Esophagus | ESCC | 7.15e-10 | 1.97e-01 | 0.1149 |
57827 | C6orf47 | P16T-E | Human | Esophagus | ESCC | 1.43e-18 | 2.71e-01 | 0.1153 |
57827 | C6orf47 | P17T-E | Human | Esophagus | ESCC | 7.34e-14 | 3.79e-01 | 0.1278 |
57827 | C6orf47 | P19T-E | Human | Esophagus | ESCC | 8.09e-06 | 5.74e-01 | 0.1662 |
57827 | C6orf47 | P20T-E | Human | Esophagus | ESCC | 5.14e-08 | 2.47e-01 | 0.1124 |
57827 | C6orf47 | P21T-E | Human | Esophagus | ESCC | 5.01e-21 | 4.32e-01 | 0.1617 |
57827 | C6orf47 | P22T-E | Human | Esophagus | ESCC | 2.23e-15 | 3.19e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf47 | SNV | Missense_Mutation | novel | c.107N>G | p.Ser36Trp | p.S36W | O95873 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.815) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
C6orf47 | SNV | Missense_Mutation | c.675N>A | p.Phe225Leu | p.F225L | O95873 | protein_coding | deleterious(0) | possibly_damaging(0.475) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
C6orf47 | SNV | Missense_Mutation | c.111N>T | p.Glu37Asp | p.E37D | O95873 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C6orf47 | deletion | Frame_Shift_Del | novel | c.512delN | p.Gly171AlafsTer12 | p.G171Afs*12 | O95873 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C6orf47 | SNV | Missense_Mutation | novel | c.260N>T | p.Arg87Ile | p.R87I | O95873 | protein_coding | deleterious_low_confidence(0) | benign(0.299) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C6orf47 | SNV | Missense_Mutation | novel | c.260N>T | p.Arg87Ile | p.R87I | O95873 | protein_coding | deleterious_low_confidence(0) | benign(0.299) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
C6orf47 | SNV | Missense_Mutation | novel | c.122N>A | p.Ser41Asn | p.S41N | O95873 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C6orf47 | SNV | Missense_Mutation | rs372568469 | c.745N>T | p.Leu249Phe | p.L249F | O95873 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf47 | deletion | In_Frame_Del | novel | c.389_436delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Val130_Leu145del | p.V130_L145del | O95873 | protein_coding | TCGA-DD-AADM-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
C6orf47 | SNV | Missense_Mutation | c.170N>C | p.Lys57Thr | p.K57T | O95873 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.666) | TCGA-78-7152-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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