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Gene: C3orf18 |
Gene summary for C3ORF18 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C3orf18 | Gene ID | 51161 |
Gene name | chromosome 3 open reading frame 18 | |
Gene Alias | G20 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9UK00 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51161 | C3orf18 | HCC1 | Human | Liver | HCC | 3.12e-03 | 2.39e+00 | 0.5336 |
51161 | C3orf18 | HCC2 | Human | Liver | HCC | 8.19e-10 | 2.47e+00 | 0.5341 |
51161 | C3orf18 | S027 | Human | Liver | HCC | 5.76e-05 | 2.69e-01 | 0.2446 |
51161 | C3orf18 | S028 | Human | Liver | HCC | 6.47e-12 | 3.51e-01 | 0.2503 |
51161 | C3orf18 | S029 | Human | Liver | HCC | 8.01e-10 | 3.22e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C3orf18 | SNV | Missense_Mutation | rs144985331 | c.304N>A | p.Asp102Asn | p.D102N | Q9UK00 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | rs144985331 | c.304N>A | p.Asp102Asn | p.D102N | Q9UK00 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
C3orf18 | SNV | Missense_Mutation | rs775853756 | c.216A>G | p.Ile72Met | p.I72M | Q9UK00 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | novel | c.322N>T | p.Asp108Tyr | p.D108Y | Q9UK00 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | novel | c.106N>G | p.Thr36Ala | p.T36A | Q9UK00 | protein_coding | tolerated(0.06) | benign(0.026) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | rs559763162 | c.167N>T | p.Thr56Met | p.T56M | Q9UK00 | protein_coding | deleterious(0.02) | benign(0.251) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | rs200548081 | c.355N>T | p.Arg119Trp | p.R119W | Q9UK00 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C3orf18 | SNV | Missense_Mutation | novel | c.258G>T | p.Lys86Asn | p.K86N | Q9UK00 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
C3orf18 | SNV | Missense_Mutation | c.136N>T | p.Asp46Tyr | p.D46Y | Q9UK00 | protein_coding | deleterious(0.04) | benign(0.439) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C3orf18 | SNV | Missense_Mutation | novel | c.383N>A | p.Thr128Asn | p.T128N | Q9UK00 | protein_coding | tolerated(0.51) | benign(0) | TCGA-D1-A1O5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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