![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C1orf116 |
Gene summary for C1ORF116 |
![]() |
Gene information | Species | Human | Gene symbol | C1orf116 | Gene ID | 79098 |
Gene name | chromosome 1 open reading frame 116 | |
Gene Alias | SARG | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BW04 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79098 | C1orf116 | LZE4T | Human | Esophagus | ESCC | 3.70e-02 | 6.12e-03 | 0.0811 |
79098 | C1orf116 | LZE24T | Human | Esophagus | ESCC | 1.91e-18 | 8.34e-01 | 0.0596 |
79098 | C1orf116 | P1T-E | Human | Esophagus | ESCC | 1.02e-04 | 5.10e-01 | 0.0875 |
79098 | C1orf116 | P4T-E | Human | Esophagus | ESCC | 9.28e-08 | 3.87e-03 | 0.1323 |
79098 | C1orf116 | P5T-E | Human | Esophagus | ESCC | 1.98e-13 | 8.21e-02 | 0.1327 |
79098 | C1orf116 | P8T-E | Human | Esophagus | ESCC | 2.92e-10 | 1.65e-01 | 0.0889 |
79098 | C1orf116 | P9T-E | Human | Esophagus | ESCC | 8.85e-04 | 1.75e-01 | 0.1131 |
79098 | C1orf116 | P10T-E | Human | Esophagus | ESCC | 2.14e-04 | -4.81e-02 | 0.116 |
79098 | C1orf116 | P15T-E | Human | Esophagus | ESCC | 1.38e-04 | -7.09e-02 | 0.1149 |
79098 | C1orf116 | P17T-E | Human | Esophagus | ESCC | 2.12e-04 | 1.98e-01 | 0.1278 |
79098 | C1orf116 | P20T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.94e-02 | 0.1124 |
79098 | C1orf116 | P21T-E | Human | Esophagus | ESCC | 5.29e-13 | 2.40e-01 | 0.1617 |
79098 | C1orf116 | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | -5.22e-02 | 0.1236 |
79098 | C1orf116 | P23T-E | Human | Esophagus | ESCC | 2.29e-09 | 4.20e-01 | 0.108 |
79098 | C1orf116 | P26T-E | Human | Esophagus | ESCC | 2.89e-10 | -3.67e-03 | 0.1276 |
79098 | C1orf116 | P27T-E | Human | Esophagus | ESCC | 3.03e-02 | -1.66e-02 | 0.1055 |
79098 | C1orf116 | P28T-E | Human | Esophagus | ESCC | 1.81e-10 | 9.25e-02 | 0.1149 |
79098 | C1orf116 | P31T-E | Human | Esophagus | ESCC | 3.78e-13 | 2.77e-01 | 0.1251 |
79098 | C1orf116 | P32T-E | Human | Esophagus | ESCC | 7.83e-03 | -9.54e-02 | 0.1666 |
79098 | C1orf116 | P36T-E | Human | Esophagus | ESCC | 1.51e-09 | 2.44e-01 | 0.1187 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf116 | SNV | Missense_Mutation | novel | c.967T>C | p.Ser323Pro | p.S323P | Q9BW04 | protein_coding | tolerated(0.06) | benign(0.043) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
C1orf116 | SNV | Missense_Mutation | c.1281G>A | p.Met427Ile | p.M427I | Q9BW04 | protein_coding | tolerated(0.07) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C1orf116 | SNV | Missense_Mutation | c.1664N>T | p.Ser555Ile | p.S555I | Q9BW04 | protein_coding | deleterious(0.01) | benign(0.211) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
C1orf116 | SNV | Missense_Mutation | novel | c.1252N>G | p.Pro418Ala | p.P418A | Q9BW04 | protein_coding | tolerated(0.15) | benign(0.395) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
C1orf116 | insertion | Nonsense_Mutation | novel | c.120_121insAGGCAGAAGAAGGTGTAGCCACACT | p.Asp41ArgfsTer6 | p.D41Rfs*6 | Q9BW04 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
C1orf116 | insertion | Frame_Shift_Ins | novel | c.1248_1249insCT | p.Ala417LeufsTer12 | p.A417Lfs*12 | Q9BW04 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
C1orf116 | insertion | Nonsense_Mutation | novel | c.1247_1248insTTAGGAAGTAAATCTTACTTATGGTTGTGA | p.Pro416_Ala417insTer | p.P416_A417ins* | Q9BW04 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
C1orf116 | insertion | Nonsense_Mutation | novel | c.139_140insTATCAGAGCTCTAGAAGGGAAAGGGGTTTGACC | p.Glu47delinsValSerGluLeuTerLysGlyLysGlyPheAspGln | p.E47delinsVSEL*KGKGFDQ | Q9BW04 | protein_coding | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
C1orf116 | SNV | Missense_Mutation | c.992N>T | p.Gly331Val | p.G331V | Q9BW04 | protein_coding | tolerated(0.11) | possibly_damaging(0.785) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C1orf116 | SNV | Missense_Mutation | novel | c.525N>C | p.Gln175His | p.Q175H | Q9BW04 | protein_coding | deleterious(0.02) | possibly_damaging(0.826) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |