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Gene: C10orf76 |
Gene summary for C10ORF76 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C10orf76 | Gene ID | 79591 |
Gene name | armadillo like helical domain containing 3 | |
Gene Alias | C10orf76 | |
Cytomap | 10q24.32 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B3KUU6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79591 | C10orf76 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.19e-18 | 3.62e-01 | 0.294 |
79591 | C10orf76 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.28e-10 | 7.66e-01 | 0.3487 |
79591 | C10orf76 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.62e-28 | 8.02e-01 | 0.281 |
79591 | C10orf76 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.17e-37 | 7.41e-01 | 0.3859 |
79591 | C10orf76 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.31e-06 | 2.95e-01 | 0.2585 |
79591 | C10orf76 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.63e-22 | 4.03e-01 | 0.3005 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C10orf76 | SNV | Missense_Mutation | c.799N>A | p.Gln267Lys | p.Q267K | Q5T2E6 | protein_coding | tolerated(0.32) | benign(0.057) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
C10orf76 | SNV | Missense_Mutation | c.372C>G | p.Ile124Met | p.I124M | Q5T2E6 | protein_coding | deleterious(0.01) | benign(0.297) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C10orf76 | SNV | Missense_Mutation | novel | c.557A>G | p.Asn186Ser | p.N186S | Q5T2E6 | protein_coding | tolerated(0.12) | benign(0.391) | TCGA-AO-A1KR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
C10orf76 | SNV | Missense_Mutation | c.799C>A | p.Gln267Lys | p.Q267K | Q5T2E6 | protein_coding | tolerated(0.32) | benign(0.057) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD | |
C10orf76 | SNV | Missense_Mutation | novel | c.1018C>T | p.Pro340Ser | p.P340S | Q5T2E6 | protein_coding | tolerated(0.35) | benign(0.023) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C10orf76 | SNV | Missense_Mutation | c.917N>G | p.Val306Gly | p.V306G | Q5T2E6 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C10orf76 | SNV | Missense_Mutation | rs769383327 | c.2062N>G | p.Ile688Val | p.I688V | Q5T2E6 | protein_coding | tolerated(0.14) | benign(0.344) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C10orf76 | SNV | Missense_Mutation | c.929G>T | p.Arg310Leu | p.R310L | Q5T2E6 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C10orf76 | SNV | Missense_Mutation | c.856N>A | p.Ala286Thr | p.A286T | Q5T2E6 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C10orf76 | SNV | Missense_Mutation | c.2055N>A | p.Phe685Leu | p.F685L | Q5T2E6 | protein_coding | tolerated(0.32) | benign(0.01) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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