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Gene: ART4 |
Gene summary for ART4 |
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Gene information | Species | Human | Gene symbol | ART4 | Gene ID | 420 |
Gene name | ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) | |
Gene Alias | ARTC4 | |
Cytomap | 12p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q93070 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
420 | ART4 | ATC13 | Human | Thyroid | ATC | 5.83e-57 | 1.23e+00 | 0.34 |
420 | ART4 | ATC5 | Human | Thyroid | ATC | 8.02e-68 | 1.30e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064711 | Thyroid | ATC | protein ADP-ribosylation | 19/6293 | 35/18723 | 9.36e-03 | 3.44e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ART4 | SNV | Missense_Mutation | novel | c.815C>A | p.Thr272Asn | p.T272N | Q93070 | protein_coding | tolerated(0.2) | benign(0.027) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ART4 | SNV | Missense_Mutation | c.413N>C | p.Arg138Thr | p.R138T | Q93070 | protein_coding | tolerated(0.6) | benign(0.03) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ART4 | SNV | Missense_Mutation | c.235C>G | p.Gln79Glu | p.Q79E | Q93070 | protein_coding | tolerated(0.18) | benign(0.072) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ART4 | SNV | Missense_Mutation | c.142N>A | p.Glu48Lys | p.E48K | Q93070 | protein_coding | tolerated(0.11) | benign(0.06) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ART4 | SNV | Missense_Mutation | novel | c.143N>G | p.Glu48Gly | p.E48G | Q93070 | protein_coding | deleterious(0.01) | benign(0.085) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
ART4 | SNV | Missense_Mutation | c.301N>T | p.His101Tyr | p.H101Y | Q93070 | protein_coding | tolerated(0.14) | benign(0.159) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ART4 | SNV | Missense_Mutation | c.475N>G | p.Leu159Val | p.L159V | Q93070 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ART4 | SNV | Missense_Mutation | novel | c.577N>A | p.His193Asn | p.H193N | Q93070 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ART4 | SNV | Missense_Mutation | c.273N>T | p.Lys91Asn | p.K91N | Q93070 | protein_coding | deleterious(0) | possibly_damaging(0.559) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ART4 | SNV | Missense_Mutation | novel | c.611N>G | p.Phe204Cys | p.F204C | Q93070 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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