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Gene: AP5Z1 |
Gene summary for AP5Z1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | AP5Z1 | Gene ID | 9907 |
Gene name | adaptor related protein complex 5 subunit zeta 1 | |
Gene Alias | KIAA0415 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | O43299 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9907 | AP5Z1 | LZE4T | Human | Esophagus | ESCC | 2.45e-05 | 1.20e-01 | 0.0811 |
9907 | AP5Z1 | LZE7T | Human | Esophagus | ESCC | 1.38e-02 | 1.92e-01 | 0.0667 |
9907 | AP5Z1 | LZE8T | Human | Esophagus | ESCC | 2.03e-08 | 2.23e-01 | 0.067 |
9907 | AP5Z1 | LZE20T | Human | Esophagus | ESCC | 3.45e-09 | 2.71e-01 | 0.0662 |
9907 | AP5Z1 | LZE22D1 | Human | Esophagus | HGIN | 1.16e-02 | 1.41e-01 | 0.0595 |
9907 | AP5Z1 | LZE22T | Human | Esophagus | ESCC | 1.71e-06 | 3.68e-01 | 0.068 |
9907 | AP5Z1 | LZE24T | Human | Esophagus | ESCC | 2.19e-11 | 2.38e-01 | 0.0596 |
9907 | AP5Z1 | LZE21T | Human | Esophagus | ESCC | 8.61e-03 | 1.61e-01 | 0.0655 |
9907 | AP5Z1 | LZE6T | Human | Esophagus | ESCC | 1.20e-03 | 1.67e-01 | 0.0845 |
9907 | AP5Z1 | P1T-E | Human | Esophagus | ESCC | 5.24e-07 | 4.10e-01 | 0.0875 |
9907 | AP5Z1 | P2T-E | Human | Esophagus | ESCC | 5.13e-11 | 1.67e-01 | 0.1177 |
9907 | AP5Z1 | P4T-E | Human | Esophagus | ESCC | 4.15e-12 | 1.95e-01 | 0.1323 |
9907 | AP5Z1 | P5T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.82e-01 | 0.1327 |
9907 | AP5Z1 | P8T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.77e-01 | 0.0889 |
9907 | AP5Z1 | P9T-E | Human | Esophagus | ESCC | 2.18e-07 | 1.81e-01 | 0.1131 |
9907 | AP5Z1 | P10T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.21e-01 | 0.116 |
9907 | AP5Z1 | P11T-E | Human | Esophagus | ESCC | 2.44e-10 | 3.68e-01 | 0.1426 |
9907 | AP5Z1 | P12T-E | Human | Esophagus | ESCC | 1.47e-19 | 2.87e-01 | 0.1122 |
9907 | AP5Z1 | P15T-E | Human | Esophagus | ESCC | 9.80e-18 | 3.30e-01 | 0.1149 |
9907 | AP5Z1 | P16T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.20e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619710 | Esophagus | HGIN | endosomal transport | 57/2587 | 230/18723 | 5.74e-06 | 1.81e-04 | 57 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00161976 | Lung | IAC | endosomal transport | 43/2061 | 230/18723 | 3.53e-04 | 5.50e-03 | 43 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
GO:00063023 | Oral cavity | OSCC | double-strand break repair | 132/7305 | 251/18723 | 7.93e-06 | 8.52e-05 | 132 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
GO:0000725 | Oral cavity | OSCC | recombinational repair | 70/7305 | 140/18723 | 5.22e-03 | 2.03e-02 | 70 |
GO:0000724 | Oral cavity | OSCC | double-strand break repair via homologous recombination | 69/7305 | 138/18723 | 5.52e-03 | 2.14e-02 | 69 |
GO:001619714 | Oral cavity | LP | endosomal transport | 98/4623 | 230/18723 | 1.65e-09 | 7.50e-08 | 98 |
GO:000630211 | Oral cavity | LP | double-strand break repair | 80/4623 | 251/18723 | 5.81e-03 | 3.46e-02 | 80 |
GO:001619718 | Thyroid | PTC | endosomal transport | 128/5968 | 230/18723 | 6.26e-14 | 3.52e-12 | 128 |
GO:00063026 | Thyroid | PTC | double-strand break repair | 103/5968 | 251/18723 | 1.30e-03 | 7.40e-03 | 103 |
GO:001619719 | Thyroid | ATC | endosomal transport | 128/6293 | 230/18723 | 4.44e-12 | 1.75e-10 | 128 |
GO:000630212 | Thyroid | ATC | double-strand break repair | 110/6293 | 251/18723 | 4.48e-04 | 2.65e-03 | 110 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP5Z1 | SNV | Missense_Mutation | novel | c.880N>T | p.Arg294Trp | p.R294W | O43299 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-4H-AAAK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | CR |
AP5Z1 | SNV | Missense_Mutation | c.1456N>A | p.Ser486Thr | p.S486T | O43299 | protein_coding | tolerated(0.36) | benign(0.302) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
AP5Z1 | SNV | Missense_Mutation | novel | c.747G>T | p.Trp249Cys | p.W249C | O43299 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A8OR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AP5Z1 | SNV | Missense_Mutation | novel | c.1336C>T | p.Leu446Phe | p.L446F | O43299 | protein_coding | tolerated(0.07) | possibly_damaging(0.58) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AP5Z1 | SNV | Missense_Mutation | novel | c.865C>G | p.Pro289Ala | p.P289A | O43299 | protein_coding | tolerated(0.07) | possibly_damaging(0.557) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD |
AP5Z1 | SNV | Missense_Mutation | rs778239868 | c.2249G>A | p.Arg750Gln | p.R750Q | O43299 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A6-2682-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | PD |
AP5Z1 | SNV | Missense_Mutation | rs763884027 | c.650N>T | p.Ala217Val | p.A217V | O43299 | protein_coding | tolerated(0.08) | benign(0.04) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
AP5Z1 | SNV | Missense_Mutation | c.2405N>T | p.Ala802Val | p.A802V | O43299 | protein_coding | deleterious(0.04) | benign(0.306) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AP5Z1 | SNV | Missense_Mutation | rs181396911 | c.1406N>T | p.Ala469Val | p.A469V | O43299 | protein_coding | tolerated(0.74) | benign(0.011) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
AP5Z1 | SNV | Missense_Mutation | novel | c.115C>T | p.Pro39Ser | p.P39S | O43299 | protein_coding | tolerated(0.33) | benign(0.029) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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