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Gene: ANKRA2 |
Gene summary for ANKRA2 |
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Gene information | Species | Human | Gene symbol | ANKRA2 | Gene ID | 57763 |
Gene name | ankyrin repeat family A member 2 | |
Gene Alias | ANKRA | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024RAN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57763 | ANKRA2 | LZE4T | Human | Esophagus | ESCC | 4.35e-04 | 2.19e-02 | 0.0811 |
57763 | ANKRA2 | LZE7T | Human | Esophagus | ESCC | 2.28e-03 | 9.10e-02 | 0.0667 |
57763 | ANKRA2 | LZE8T | Human | Esophagus | ESCC | 1.85e-05 | 1.77e-01 | 0.067 |
57763 | ANKRA2 | LZE20T | Human | Esophagus | ESCC | 2.29e-02 | 5.70e-02 | 0.0662 |
57763 | ANKRA2 | LZE24T | Human | Esophagus | ESCC | 1.87e-13 | 4.99e-01 | 0.0596 |
57763 | ANKRA2 | P2T-E | Human | Esophagus | ESCC | 3.23e-23 | 4.15e-01 | 0.1177 |
57763 | ANKRA2 | P4T-E | Human | Esophagus | ESCC | 1.65e-09 | 1.26e-01 | 0.1323 |
57763 | ANKRA2 | P5T-E | Human | Esophagus | ESCC | 6.13e-03 | -6.03e-02 | 0.1327 |
57763 | ANKRA2 | P8T-E | Human | Esophagus | ESCC | 2.22e-09 | 1.83e-01 | 0.0889 |
57763 | ANKRA2 | P9T-E | Human | Esophagus | ESCC | 8.17e-13 | 1.62e-01 | 0.1131 |
57763 | ANKRA2 | P10T-E | Human | Esophagus | ESCC | 3.76e-13 | 2.23e-01 | 0.116 |
57763 | ANKRA2 | P12T-E | Human | Esophagus | ESCC | 5.56e-16 | 5.13e-01 | 0.1122 |
57763 | ANKRA2 | P15T-E | Human | Esophagus | ESCC | 1.23e-16 | 3.13e-01 | 0.1149 |
57763 | ANKRA2 | P16T-E | Human | Esophagus | ESCC | 5.59e-21 | 1.49e-01 | 0.1153 |
57763 | ANKRA2 | P17T-E | Human | Esophagus | ESCC | 3.26e-02 | 5.37e-04 | 0.1278 |
57763 | ANKRA2 | P20T-E | Human | Esophagus | ESCC | 1.27e-13 | 2.45e-01 | 0.1124 |
57763 | ANKRA2 | P21T-E | Human | Esophagus | ESCC | 4.80e-21 | 1.57e-01 | 0.1617 |
57763 | ANKRA2 | P22T-E | Human | Esophagus | ESCC | 1.03e-19 | 2.46e-01 | 0.1236 |
57763 | ANKRA2 | P23T-E | Human | Esophagus | ESCC | 1.14e-11 | 3.86e-01 | 0.108 |
57763 | ANKRA2 | P24T-E | Human | Esophagus | ESCC | 6.53e-08 | 5.78e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:0043254110 | Oral cavity | LP | regulation of protein-containing complex assembly | 163/4623 | 428/18723 | 3.72e-10 | 1.92e-08 | 163 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0043254210 | Thyroid | ATC | regulation of protein-containing complex assembly | 225/6293 | 428/18723 | 2.72e-16 | 2.33e-14 | 225 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRA2 | SNV | Missense_Mutation | c.103N>T | p.Pro35Ser | p.P35S | Q9H9E1 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-D8-A1JF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ANKRA2 | SNV | Missense_Mutation | rs749997797 | c.659C>T | p.Ser220Leu | p.S220L | Q9H9E1 | protein_coding | tolerated(1) | benign(0.279) | TCGA-5M-AATE-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ANKRA2 | SNV | Missense_Mutation | novel | c.203N>G | p.Phe68Cys | p.F68C | Q9H9E1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.971) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | rs200934847 | c.176G>A | p.Arg59Gln | p.R59Q | Q9H9E1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.885) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | rs778296728 | c.503N>A | p.Arg168His | p.R168H | Q9H9E1 | protein_coding | tolerated(0.3) | benign(0.09) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | novel | c.410N>T | p.Arg137Ile | p.R137I | Q9H9E1 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | novel | c.323G>A | p.Gly108Glu | p.G108E | Q9H9E1 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-AX-A3FX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ANKRA2 | SNV | Missense_Mutation | novel | c.604N>A | p.Leu202Ile | p.L202I | Q9H9E1 | protein_coding | tolerated(0.1) | probably_damaging(0.979) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | novel | c.626N>C | p.Gln209Pro | p.Q209P | Q9H9E1 | protein_coding | tolerated(0.11) | possibly_damaging(0.447) | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKRA2 | SNV | Missense_Mutation | c.74C>T | p.Thr25Ile | p.T25I | Q9H9E1 | protein_coding | tolerated_low_confidence(0.05) | benign(0.003) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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