Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ABI3BP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ABI3BP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ABI3BP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ABI3BP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABI3BP | SNV | Missense_Mutation | | c.976G>C | p.Glu326Gln | p.E326Q | Q7Z7G0 | protein_coding | tolerated(0.06) | possibly_damaging(0.521) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ABI3BP | SNV | Missense_Mutation | novel | c.2747N>A | p.Pro916Gln | p.P916Q | Q7Z7G0 | protein_coding | deleterious(0) | possibly_damaging(0.778) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ABI3BP | SNV | Missense_Mutation | | c.2581N>A | p.Glu861Lys | p.E861K | Q7Z7G0 | protein_coding | deleterious(0.01) | benign(0.217) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
ABI3BP | SNV | Missense_Mutation | | c.1198N>C | p.Glu400Gln | p.E400Q | Q7Z7G0 | protein_coding | deleterious(0.04) | benign(0.229) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ABI3BP | SNV | Missense_Mutation | | c.1132N>A | p.Asp378Asn | p.D378N | Q7Z7G0 | protein_coding | tolerated(0.07) | benign(0.396) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ABI3BP | SNV | Missense_Mutation | | c.1295N>T | p.Thr432Ile | p.T432I | Q7Z7G0 | protein_coding | deleterious(0) | possibly_damaging(0.623) | TCGA-AR-A24U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ABI3BP | SNV | Missense_Mutation | | c.1805C>T | p.Pro602Leu | p.P602L | Q7Z7G0 | protein_coding | tolerated(0.09) | possibly_damaging(0.476) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABI3BP | SNV | Missense_Mutation | | c.2973N>C | p.Leu991Phe | p.L991F | Q7Z7G0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ABI3BP | SNV | Missense_Mutation | | c.478N>A | p.Asp160Asn | p.D160N | Q7Z7G0 | protein_coding | deleterious(0.02) | possibly_damaging(0.89) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ABI3BP | SNV | Missense_Mutation | novel | c.496N>T | p.Arg166Cys | p.R166C | Q7Z7G0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |