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Gene: ZNF766 |
Gene summary for ZNF766 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF766 | Gene ID | 90321 |
Gene name | zinc finger protein 766 | |
Gene Alias | ZNF766 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5HY98 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90321 | ZNF766 | LZE4T | Human | Esophagus | ESCC | 1.52e-04 | 1.77e-01 | 0.0811 |
90321 | ZNF766 | LZE24T | Human | Esophagus | ESCC | 1.63e-10 | 2.73e-01 | 0.0596 |
90321 | ZNF766 | LZE21T | Human | Esophagus | ESCC | 4.58e-02 | 2.74e-01 | 0.0655 |
90321 | ZNF766 | P1T-E | Human | Esophagus | ESCC | 7.04e-03 | 1.97e-01 | 0.0875 |
90321 | ZNF766 | P2T-E | Human | Esophagus | ESCC | 1.42e-17 | 3.09e-01 | 0.1177 |
90321 | ZNF766 | P4T-E | Human | Esophagus | ESCC | 6.05e-17 | 2.90e-01 | 0.1323 |
90321 | ZNF766 | P5T-E | Human | Esophagus | ESCC | 5.22e-04 | 9.79e-02 | 0.1327 |
90321 | ZNF766 | P8T-E | Human | Esophagus | ESCC | 3.41e-24 | 4.03e-01 | 0.0889 |
90321 | ZNF766 | P9T-E | Human | Esophagus | ESCC | 1.72e-05 | 1.23e-01 | 0.1131 |
90321 | ZNF766 | P10T-E | Human | Esophagus | ESCC | 4.57e-32 | 5.94e-01 | 0.116 |
90321 | ZNF766 | P11T-E | Human | Esophagus | ESCC | 1.01e-09 | 3.37e-01 | 0.1426 |
90321 | ZNF766 | P12T-E | Human | Esophagus | ESCC | 5.45e-19 | 3.76e-01 | 0.1122 |
90321 | ZNF766 | P15T-E | Human | Esophagus | ESCC | 6.88e-18 | 3.36e-01 | 0.1149 |
90321 | ZNF766 | P16T-E | Human | Esophagus | ESCC | 1.57e-11 | 2.31e-01 | 0.1153 |
90321 | ZNF766 | P17T-E | Human | Esophagus | ESCC | 9.48e-08 | 3.18e-01 | 0.1278 |
90321 | ZNF766 | P20T-E | Human | Esophagus | ESCC | 2.50e-08 | 2.42e-01 | 0.1124 |
90321 | ZNF766 | P21T-E | Human | Esophagus | ESCC | 1.59e-07 | 1.36e-01 | 0.1617 |
90321 | ZNF766 | P22T-E | Human | Esophagus | ESCC | 8.94e-13 | 2.51e-01 | 0.1236 |
90321 | ZNF766 | P23T-E | Human | Esophagus | ESCC | 1.02e-14 | 3.94e-01 | 0.108 |
90321 | ZNF766 | P24T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.50e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | |
Skin | AK | |
Skin | SCCIS | |
Skin | cSCC | |
Thyroid | HT |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF766 | SNV | Missense_Mutation | rs375042302 | c.440N>T | p.Ser147Leu | p.S147L | Q5HY98 | protein_coding | tolerated(0.13) | benign(0.011) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
ZNF766 | SNV | Missense_Mutation | novel | c.935C>T | p.Ser312Leu | p.S312L | Q5HY98 | protein_coding | deleterious(0.01) | possibly_damaging(0.48) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF766 | SNV | Missense_Mutation | novel | c.1196N>T | p.Ala399Val | p.A399V | Q5HY98 | protein_coding | tolerated(0.26) | benign(0.017) | TCGA-VS-A8QH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
ZNF766 | insertion | Frame_Shift_Ins | novel | c.933_934insGTGGA | p.Ser312ValfsTer5 | p.S312Vfs*5 | Q5HY98 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
ZNF766 | SNV | Missense_Mutation | c.956N>T | p.Arg319Ile | p.R319I | Q5HY98 | protein_coding | tolerated(0.11) | possibly_damaging(0.544) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF766 | SNV | Missense_Mutation | c.1359N>C | p.Trp453Cys | p.W453C | Q5HY98 | protein_coding | tolerated(0.16) | benign(0) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF766 | SNV | Missense_Mutation | c.961N>T | p.His321Tyr | p.H321Y | Q5HY98 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-F4-6460-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
ZNF766 | SNV | Missense_Mutation | rs752315701 | c.40N>A | p.Val14Met | p.V14M | Q5HY98 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF766 | SNV | Missense_Mutation | c.972N>T | p.Glu324Asp | p.E324D | Q5HY98 | protein_coding | deleterious(0.02) | possibly_damaging(0.813) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF766 | SNV | Missense_Mutation | rs766094251 | c.845G>A | p.Arg282Gln | p.R282Q | Q5HY98 | protein_coding | tolerated(1) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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