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Gene: ZNF730 |
Gene summary for ZNF730 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF730 | Gene ID | 100129543 |
| Gene name | zinc finger protein 730 | |
| Gene Alias | ZNF730 | |
| Cytomap | 19p12 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZMV8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100129543 | ZNF730 | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.80e-11 | 7.52e-01 | 0.0446 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Esophagus | ESCC |  |
| Skin | AK |  |
| Skin | SCCIS |  |
| Skin | cSCC |  |
| Thyroid | HT |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF730 | SNV | Missense_Mutation | c.169N>A | p.Glu57Lys | p.E57K | Q6ZMV8 | protein_coding | tolerated(0.06) | benign(0.267) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF730 | SNV | Missense_Mutation | c.1172N>T | p.Thr391Ile | p.T391I | Q6ZMV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.578) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF730 | SNV | Missense_Mutation | novel | c.1497N>T | p.Lys499Asn | p.K499N | Q6ZMV8 | protein_coding | deleterious(0.03) | benign(0.114) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZNF730 | SNV | Missense_Mutation | novel | c.438N>C | p.Gln146His | p.Q146H | Q6ZMV8 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF730 | SNV | Missense_Mutation | c.146N>T | p.Lys49Met | p.K49M | Q6ZMV8 | protein_coding | deleterious(0.01) | possibly_damaging(0.661) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| ZNF730 | SNV | Missense_Mutation | c.89N>A | p.Arg30Lys | p.R30K | Q6ZMV8 | protein_coding | deleterious(0.04) | benign(0.41) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF730 | SNV | Missense_Mutation | c.1350N>C | p.Lys450Asn | p.K450N | Q6ZMV8 | protein_coding | deleterious(0.02) | possibly_damaging(0.753) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF730 | SNV | Missense_Mutation | rs760090120 | c.583C>A | p.His195Asn | p.H195N | Q6ZMV8 | protein_coding | deleterious(0.02) | benign(0.152) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF730 | SNV | Missense_Mutation | novel | c.827G>A | p.Arg276Lys | p.R276K | Q6ZMV8 | protein_coding | tolerated(0.75) | benign(0.019) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| ZNF730 | SNV | Missense_Mutation | c.847N>A | p.Pro283Thr | p.P283T | Q6ZMV8 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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