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Gene: ZNF714 |
Gene summary for ZNF714 |
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Gene information | Species | Human | Gene symbol | ZNF714 | Gene ID | 148206 |
Gene name | zinc finger protein 714 | |
Gene Alias | ZNF714 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087WU35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148206 | ZNF714 | HCC1 | Human | Liver | HCC | 4.03e-13 | 1.27e+00 | 0.5336 |
148206 | ZNF714 | HCC2 | Human | Liver | HCC | 5.80e-23 | 2.89e+00 | 0.5341 |
148206 | ZNF714 | HCC5 | Human | Liver | HCC | 1.20e-19 | 1.45e+00 | 0.4932 |
148206 | ZNF714 | S014 | Human | Liver | HCC | 4.60e-02 | 1.77e-01 | 0.2254 |
148206 | ZNF714 | S015 | Human | Liver | HCC | 9.16e-07 | 2.93e-01 | 0.2375 |
148206 | ZNF714 | S016 | Human | Liver | HCC | 3.23e-06 | 1.79e-01 | 0.2243 |
148206 | ZNF714 | male-WTA | Human | Thyroid | PTC | 6.03e-26 | 2.35e-01 | 0.1037 |
148206 | ZNF714 | PTC01 | Human | Thyroid | PTC | 1.57e-21 | 4.90e-01 | 0.1899 |
148206 | ZNF714 | PTC03 | Human | Thyroid | PTC | 1.88e-02 | 3.66e-01 | 0.1784 |
148206 | ZNF714 | PTC04 | Human | Thyroid | PTC | 2.65e-14 | 4.43e-01 | 0.1927 |
148206 | ZNF714 | PTC05 | Human | Thyroid | PTC | 4.00e-21 | 1.01e+00 | 0.2065 |
148206 | ZNF714 | PTC06 | Human | Thyroid | PTC | 1.34e-30 | 9.68e-01 | 0.2057 |
148206 | ZNF714 | PTC07 | Human | Thyroid | PTC | 6.80e-34 | 8.18e-01 | 0.2044 |
148206 | ZNF714 | ATC12 | Human | Thyroid | ATC | 1.04e-14 | 4.83e-02 | 0.34 |
148206 | ZNF714 | ATC13 | Human | Thyroid | ATC | 9.59e-16 | 8.97e-02 | 0.34 |
148206 | ZNF714 | ATC4 | Human | Thyroid | ATC | 6.24e-10 | 1.14e-01 | 0.34 |
148206 | ZNF714 | ATC5 | Human | Thyroid | ATC | 1.55e-13 | 1.30e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF714 | SNV | Missense_Mutation | novel | c.865N>A | p.Glu289Lys | p.E289K | protein_coding | deleterious(0.04) | possibly_damaging(0.526) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
ZNF714 | SNV | Missense_Mutation | novel | c.925N>A | p.Gly309Arg | p.G309R | protein_coding | tolerated(0.07) | probably_damaging(0.96) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF714 | SNV | Missense_Mutation | novel | c.510N>T | p.Glu170Asp | p.E170D | protein_coding | tolerated(0.06) | probably_damaging(0.97) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF714 | SNV | Missense_Mutation | novel | c.1445N>G | p.Lys482Arg | p.K482R | protein_coding | tolerated(0.05) | benign(0.154) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ZNF714 | SNV | Missense_Mutation | novel | c.278N>A | p.Val93Asp | p.V93D | protein_coding | tolerated(1) | benign(0) | TCGA-D8-A1XR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
ZNF714 | SNV | Missense_Mutation | novel | c.494G>C | p.Arg165Thr | p.R165T | protein_coding | tolerated(0.07) | possibly_damaging(0.699) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
ZNF714 | insertion | In_Frame_Ins | novel | c.432_433insATA | p.Pro144_Phe145insIle | p.P144_F145insI | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | |||
ZNF714 | insertion | In_Frame_Ins | novel | c.434_435insATA | p.Phe145delinsLeuTyr | p.F145delinsLY | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | |||
ZNF714 | insertion | Frame_Shift_Ins | novel | c.608_609insGTTAC | p.Cys203TrpfsTer21 | p.C203Wfs*21 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF714 | SNV | Missense_Mutation | rs766891771 | c.598N>T | p.Pro200Ser | p.P200S | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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