![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF554 |
Gene summary for ZNF554 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF554 | Gene ID | 115196 |
Gene name | zinc finger protein 554 | |
Gene Alias | ZNF554 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B3KNM4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115196 | ZNF554 | HCC1 | Human | Liver | HCC | 9.48e-18 | 1.65e+00 | 0.5336 |
115196 | ZNF554 | HCC2 | Human | Liver | HCC | 1.74e-24 | 2.08e+00 | 0.5341 |
115196 | ZNF554 | HCC5 | Human | Liver | HCC | 4.49e-34 | 2.03e+00 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF554 | SNV | Missense_Mutation | c.1019G>T | p.Ser340Ile | p.S340I | Q86TJ5 | protein_coding | tolerated(0.23) | benign(0.035) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
ZNF554 | SNV | Missense_Mutation | rs757079549 | c.809N>A | p.Arg270Gln | p.R270Q | Q86TJ5 | protein_coding | tolerated(0.77) | benign(0) | TCGA-AR-A24R-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ZNF554 | SNV | Missense_Mutation | c.1126N>A | p.Gly376Arg | p.G376R | Q86TJ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ZNF554 | insertion | Frame_Shift_Ins | novel | c.1230dupT | p.Glu411Ter | p.E411* | Q86TJ5 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
ZNF554 | insertion | In_Frame_Ins | novel | c.1232_1233insCTATCCACAACAAAATCA | p.Glu411delinsAspTyrProGlnGlnAsnGln | p.E411delinsDYPQQNQ | Q86TJ5 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
ZNF554 | SNV | Missense_Mutation | rs367609998 | c.1583N>T | p.Ala528Val | p.A528V | Q86TJ5 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF554 | SNV | Missense_Mutation | c.1204C>T | p.His402Tyr | p.H402Y | Q86TJ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-6648-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD | |
ZNF554 | SNV | Missense_Mutation | c.97N>A | p.Ala33Thr | p.A33T | Q86TJ5 | protein_coding | tolerated(0.57) | probably_damaging(0.992) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF554 | SNV | Missense_Mutation | c.812G>T | p.Arg271Ile | p.R271I | Q86TJ5 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF554 | SNV | Missense_Mutation | novel | c.266A>G | p.Asn89Ser | p.N89S | Q86TJ5 | protein_coding | tolerated(0.41) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |