TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF316 | CD8TEX | Breast | Precancer | AC008105.3,IFNG-AS1,COMTD1, etc. | 1.48e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
ZNF316 | CD8TEXINT | Colorectum | CRC | ZNF808,CHCHD6,FBXL18, etc. | 3.21e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_CRC/regulons_activity_in_dotplot.png) |
ZNF316 | CD8TEXINT | Colorectum | FAP | ZNF808,CHCHD6,FBXL18, etc. | 3.13e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_FAP/regulons_activity_in_dotplot.png) |
ZNF316 | TH17 | Colorectum | Healthy | ZNF808,CHCHD6,FBXL18, etc. | 3.04e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF316 | TFH | Colorectum | MSI-H | ZNF808,CHCHD6,FBXL18, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF316 | TH1 | Colorectum | MSI-H | ZNF808,CHCHD6,FBXL18, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF316 | ILC | Colorectum | MSI-H | ZNF808,CHCHD6,FBXL18, etc. | 1.45e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF316 | CD4TN | Colorectum | MSI-H | ZNF808,CHCHD6,FBXL18, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
ZNF316 | ILC | Colorectum | MSS | ZNF808,CHCHD6,FBXL18, etc. | 5.78e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSS/regulons_activity_in_dotplot.png) |
ZNF316 | LYMEND | Endometrium | AEH | LAMC2,SGCD,MMP7, etc. | 7.51e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF316 | SNV | Missense_Mutation | novel | c.664N>T | p.Pro222Ser | p.P222S | A6NFI3 | protein_coding | deleterious(0.04) | probably_damaging(0.97) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.1439N>T | p.Thr480Met | p.T480M | A6NFI3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EW-A6SA-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | rs566698996 | c.161N>T | p.Glu54Val | p.E54V | A6NFI3 | protein_coding | tolerated_low_confidence(0.13) | unknown(0) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.1301N>A | p.Cys434Tyr | p.C434Y | A6NFI3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.668N>A | p.Arg223Gln | p.R223Q | A6NFI3 | protein_coding | tolerated(0.24) | benign(0.129) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.722N>T | p.Thr241Met | p.T241M | A6NFI3 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.303G>T | p.Gln101His | p.Q101H | A6NFI3 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.95) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ZNF316 | SNV | Missense_Mutation | rs566698996 | c.161N>T | p.Glu54Val | p.E54V | A6NFI3 | protein_coding | tolerated_low_confidence(0.13) | unknown(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | novel | c.239N>G | p.Asp80Gly | p.D80G | A6NFI3 | protein_coding | tolerated_low_confidence(0.28) | unknown(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF316 | SNV | Missense_Mutation | rs377600054 | c.317G>A | p.Arg106His | p.R106H | A6NFI3 | protein_coding | tolerated_low_confidence(0.56) | benign(0.001) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |