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Gene: ZNF224 |
Gene summary for ZNF224 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF224 | Gene ID | 7767 |
Gene name | zinc finger protein 224 | |
Gene Alias | BMZF-2 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NZL3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7767 | ZNF224 | LZE4T | Human | Esophagus | ESCC | 8.07e-03 | 1.40e-01 | 0.0811 |
7767 | ZNF224 | LZE7T | Human | Esophagus | ESCC | 3.58e-03 | 1.54e-01 | 0.0667 |
7767 | ZNF224 | LZE8T | Human | Esophagus | ESCC | 9.12e-04 | 1.22e-01 | 0.067 |
7767 | ZNF224 | LZE20T | Human | Esophagus | ESCC | 2.17e-02 | 9.65e-02 | 0.0662 |
7767 | ZNF224 | LZE24T | Human | Esophagus | ESCC | 7.83e-09 | 2.23e-01 | 0.0596 |
7767 | ZNF224 | P1T-E | Human | Esophagus | ESCC | 2.15e-05 | 2.90e-01 | 0.0875 |
7767 | ZNF224 | P2T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.90e-01 | 0.1177 |
7767 | ZNF224 | P4T-E | Human | Esophagus | ESCC | 5.31e-06 | 1.67e-01 | 0.1323 |
7767 | ZNF224 | P5T-E | Human | Esophagus | ESCC | 7.90e-03 | 5.39e-02 | 0.1327 |
7767 | ZNF224 | P8T-E | Human | Esophagus | ESCC | 3.41e-42 | 6.84e-01 | 0.0889 |
7767 | ZNF224 | P9T-E | Human | Esophagus | ESCC | 3.99e-02 | 1.06e-01 | 0.1131 |
7767 | ZNF224 | P10T-E | Human | Esophagus | ESCC | 1.15e-45 | 6.33e-01 | 0.116 |
7767 | ZNF224 | P11T-E | Human | Esophagus | ESCC | 1.06e-11 | 3.66e-01 | 0.1426 |
7767 | ZNF224 | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.52e-01 | 0.1122 |
7767 | ZNF224 | P15T-E | Human | Esophagus | ESCC | 5.40e-05 | 1.41e-01 | 0.1149 |
7767 | ZNF224 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 7.35e-02 | 0.1153 |
7767 | ZNF224 | P17T-E | Human | Esophagus | ESCC | 3.40e-04 | 2.46e-01 | 0.1278 |
7767 | ZNF224 | P20T-E | Human | Esophagus | ESCC | 1.45e-07 | 2.04e-01 | 0.1124 |
7767 | ZNF224 | P21T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.29e-02 | 0.1617 |
7767 | ZNF224 | P22T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.61e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | |
Skin | AK | |
Skin | SCCIS | |
Skin | cSCC | |
Thyroid | HT |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF224 | SNV | Missense_Mutation | rs3746323 | c.1516N>G | p.His506Asp | p.H506D | Q9NZL3 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF224 | SNV | Missense_Mutation | c.905G>C | p.Arg302Thr | p.R302T | Q9NZL3 | protein_coding | tolerated(0.41) | benign(0.215) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF224 | SNV | Missense_Mutation | c.1826C>T | p.Ser609Leu | p.S609L | Q9NZL3 | protein_coding | tolerated(0.12) | probably_damaging(0.987) | TCGA-BH-A202-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF224 | insertion | In_Frame_Ins | novel | c.1084_1085insGCTCCAACTCCTGGGTTCTTGCCATTCTCCTGCCTCAGCCTCCCGAGT | p.His362delinsArgSerAsnSerTrpValLeuAlaIleLeuLeuProGlnProProGluTyr | p.H362delinsRSNSWVLAILLPQPPEY | Q9NZL3 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF224 | SNV | Missense_Mutation | c.1200N>G | p.Phe400Leu | p.F400L | Q9NZL3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
ZNF224 | SNV | Missense_Mutation | c.399N>C | p.Gln133His | p.Q133H | Q9NZL3 | protein_coding | tolerated(0.24) | benign(0.127) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF224 | SNV | Missense_Mutation | novel | c.240N>A | p.Asp80Glu | p.D80E | Q9NZL3 | protein_coding | tolerated(0.83) | benign(0.029) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF224 | SNV | Missense_Mutation | rs763079230 | c.976N>T | p.Arg326Cys | p.R326C | Q9NZL3 | protein_coding | tolerated(0.1) | probably_damaging(0.93) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF224 | SNV | Missense_Mutation | c.1684N>T | p.His562Tyr | p.H562Y | Q9NZL3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF224 | SNV | Missense_Mutation | rs3208192 | c.1613G>A | p.Arg538Lys | p.R538K | Q9NZL3 | protein_coding | tolerated(1) | benign(0.03) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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