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Gene: UBALD1 |
Gene summary for UBALD1 |
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Gene information | Species | Human | Gene symbol | UBALD1 | Gene ID | 124402 |
Gene name | UBA like domain containing 1 | |
Gene Alias | FAM100A | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | K7EM88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
124402 | UBALD1 | LZE4T | Human | Esophagus | ESCC | 1.83e-03 | 2.26e-02 | 0.0811 |
124402 | UBALD1 | LZE7T | Human | Esophagus | ESCC | 1.43e-07 | 2.15e-01 | 0.0667 |
124402 | UBALD1 | LZE8T | Human | Esophagus | ESCC | 2.25e-06 | 1.57e-01 | 0.067 |
124402 | UBALD1 | LZE20T | Human | Esophagus | ESCC | 7.21e-08 | 9.97e-02 | 0.0662 |
124402 | UBALD1 | LZE22D1 | Human | Esophagus | HGIN | 1.11e-03 | 1.55e-01 | 0.0595 |
124402 | UBALD1 | LZE22T | Human | Esophagus | ESCC | 4.20e-02 | 2.43e-01 | 0.068 |
124402 | UBALD1 | LZE24T | Human | Esophagus | ESCC | 4.70e-21 | 7.66e-01 | 0.0596 |
124402 | UBALD1 | LZE21T | Human | Esophagus | ESCC | 2.39e-02 | 3.50e-01 | 0.0655 |
124402 | UBALD1 | P1T-E | Human | Esophagus | ESCC | 2.15e-11 | 5.51e-01 | 0.0875 |
124402 | UBALD1 | P2T-E | Human | Esophagus | ESCC | 1.81e-37 | 7.65e-01 | 0.1177 |
124402 | UBALD1 | P4T-E | Human | Esophagus | ESCC | 7.34e-16 | 2.96e-01 | 0.1323 |
124402 | UBALD1 | P5T-E | Human | Esophagus | ESCC | 7.05e-25 | 4.36e-01 | 0.1327 |
124402 | UBALD1 | P8T-E | Human | Esophagus | ESCC | 2.45e-32 | 6.19e-01 | 0.0889 |
124402 | UBALD1 | P9T-E | Human | Esophagus | ESCC | 1.45e-10 | 3.44e-01 | 0.1131 |
124402 | UBALD1 | P10T-E | Human | Esophagus | ESCC | 2.38e-18 | 2.68e-01 | 0.116 |
124402 | UBALD1 | P11T-E | Human | Esophagus | ESCC | 4.44e-14 | 3.71e-01 | 0.1426 |
124402 | UBALD1 | P12T-E | Human | Esophagus | ESCC | 2.61e-35 | 7.54e-01 | 0.1122 |
124402 | UBALD1 | P15T-E | Human | Esophagus | ESCC | 6.80e-25 | 5.83e-01 | 0.1149 |
124402 | UBALD1 | P16T-E | Human | Esophagus | ESCC | 2.18e-14 | 3.13e-01 | 0.1153 |
124402 | UBALD1 | P17T-E | Human | Esophagus | ESCC | 1.44e-07 | 3.50e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBALD1 | insertion | Frame_Shift_Ins | novel | c.125_126insGA | p.Leu43ThrfsTer20 | p.L43Tfs*20 | Q8TB05 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
UBALD1 | insertion | Frame_Shift_Ins | novel | c.124_125insGCGGGGCT | p.Ala42GlyfsTer23 | p.A42Gfs*23 | Q8TB05 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
UBALD1 | SNV | Missense_Mutation | c.475N>C | p.Ala159Pro | p.A159P | Q8TB05 | protein_coding | deleterious_low_confidence(0.01) | benign(0.005) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBALD1 | SNV | Missense_Mutation | novel | c.5N>G | p.Ser2Cys | p.S2C | Q8TB05 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-55-7910-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
UBALD1 | deletion | Frame_Shift_Del | novel | c.140delT | p.Phe47SerfsTer15 | p.F47Sfs*15 | Q8TB05 | protein_coding | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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