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Gene: TTLL7 |
Gene summary for TTLL7 |
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Gene information | Species | Human | Gene symbol | TTLL7 | Gene ID | 79739 |
Gene name | tubulin tyrosine ligase like 7 | |
Gene Alias | TTLL7 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q6ZT98 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79739 | TTLL7 | LZE4T | Human | Esophagus | ESCC | 3.29e-05 | 1.75e-01 | 0.0811 |
79739 | TTLL7 | LZE7T | Human | Esophagus | ESCC | 5.95e-18 | 8.51e-01 | 0.0667 |
79739 | TTLL7 | P2T-E | Human | Esophagus | ESCC | 5.83e-09 | 1.73e-01 | 0.1177 |
79739 | TTLL7 | P8T-E | Human | Esophagus | ESCC | 1.50e-05 | 1.70e-01 | 0.0889 |
79739 | TTLL7 | P9T-E | Human | Esophagus | ESCC | 1.67e-03 | 9.06e-02 | 0.1131 |
79739 | TTLL7 | P10T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.51e-01 | 0.116 |
79739 | TTLL7 | P11T-E | Human | Esophagus | ESCC | 8.50e-07 | 3.98e-01 | 0.1426 |
79739 | TTLL7 | P12T-E | Human | Esophagus | ESCC | 4.96e-06 | 1.97e-01 | 0.1122 |
79739 | TTLL7 | P19T-E | Human | Esophagus | ESCC | 4.91e-07 | 5.28e-01 | 0.1662 |
79739 | TTLL7 | P26T-E | Human | Esophagus | ESCC | 6.65e-18 | 3.68e-01 | 0.1276 |
79739 | TTLL7 | P27T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.74e-01 | 0.1055 |
79739 | TTLL7 | P30T-E | Human | Esophagus | ESCC | 5.44e-10 | 4.21e-01 | 0.137 |
79739 | TTLL7 | P32T-E | Human | Esophagus | ESCC | 4.45e-19 | 4.09e-01 | 0.1666 |
79739 | TTLL7 | P37T-E | Human | Esophagus | ESCC | 1.74e-08 | 1.17e-01 | 0.1371 |
79739 | TTLL7 | P47T-E | Human | Esophagus | ESCC | 3.59e-02 | 9.16e-02 | 0.1067 |
79739 | TTLL7 | P48T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.61e-01 | 0.0959 |
79739 | TTLL7 | P49T-E | Human | Esophagus | ESCC | 3.41e-07 | 5.01e-01 | 0.1768 |
79739 | TTLL7 | P52T-E | Human | Esophagus | ESCC | 8.38e-06 | 1.70e-01 | 0.1555 |
79739 | TTLL7 | P57T-E | Human | Esophagus | ESCC | 5.71e-03 | 1.65e-01 | 0.0926 |
79739 | TTLL7 | P62T-E | Human | Esophagus | ESCC | 9.23e-03 | 1.29e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTLL7 | SNV | Missense_Mutation | c.1060N>G | p.Pro354Ala | p.P354A | Q6ZT98 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
TTLL7 | SNV | Missense_Mutation | novel | c.1934C>A | p.Ser645Tyr | p.S645Y | Q6ZT98 | protein_coding | tolerated_low_confidence(0.08) | benign(0.321) | TCGA-A2-A25D-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
TTLL7 | SNV | Missense_Mutation | rs772312251 | c.2368N>A | p.Gly790Arg | p.G790R | Q6ZT98 | protein_coding | deleterious(0.03) | possibly_damaging(0.799) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | novel | c.2426N>G | p.Leu809Arg | p.L809R | Q6ZT98 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
TTLL7 | SNV | Missense_Mutation | novel | c.1241N>T | p.Ser414Leu | p.S414L | Q6ZT98 | protein_coding | tolerated(0.08) | probably_damaging(0.919) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
TTLL7 | SNV | Missense_Mutation | novel | c.2160A>C | p.Lys720Asn | p.K720N | Q6ZT98 | protein_coding | deleterious(0.04) | probably_damaging(0.917) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | novel | c.2068G>T | p.Asp690Tyr | p.D690Y | Q6ZT98 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | rs769393930 | c.389G>A | p.Arg130Gln | p.R130Q | Q6ZT98 | protein_coding | deleterious(0.01) | benign(0.184) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL7 | SNV | Missense_Mutation | c.149N>C | p.Phe50Ser | p.F50S | Q6ZT98 | protein_coding | deleterious(0) | benign(0.212) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TTLL7 | SNV | Missense_Mutation | c.526N>A | p.Gly176Ser | p.G176S | Q6ZT98 | protein_coding | tolerated(0.53) | benign(0.244) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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