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Gene: TTC7B |
Gene summary for TTC7B |
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Gene information | Species | Human | Gene symbol | TTC7B | Gene ID | 145567 |
Gene name | tetratricopeptide repeat domain 7B | |
Gene Alias | TTC7L1 | |
Cytomap | 14q32.11 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q6PIF1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
145567 | TTC7B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.98e-09 | 2.12e-01 | 0.0155 |
145567 | TTC7B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-08 | 3.36e-01 | -0.1808 |
145567 | TTC7B | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.43e-10 | 7.98e-01 | 0.0216 |
145567 | TTC7B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-17 | 8.05e-01 | -0.0811 |
145567 | TTC7B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.16e-03 | 1.41e-01 | -0.1088 |
145567 | TTC7B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.87e-20 | 4.92e-01 | -0.1954 |
145567 | TTC7B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.46e-09 | 1.02e+00 | -0.2196 |
145567 | TTC7B | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.43e-22 | 6.60e-01 | -0.1207 |
145567 | TTC7B | HTA11_83_2000001011 | Human | Colorectum | SER | 8.56e-16 | 5.65e-01 | -0.1526 |
145567 | TTC7B | HTA11_696_2000001011 | Human | Colorectum | AD | 8.03e-39 | 8.99e-01 | -0.1464 |
145567 | TTC7B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.43e-29 | 6.87e-01 | -0.1001 |
145567 | TTC7B | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.41e-42 | 9.55e-01 | -0.059 |
145567 | TTC7B | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.01e-03 | 4.24e-01 | -0.1706 |
145567 | TTC7B | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.95e-06 | 4.21e-01 | -0.1462 |
145567 | TTC7B | HTA11_546_2000001011 | Human | Colorectum | AD | 5.07e-07 | 3.96e-01 | -0.0842 |
145567 | TTC7B | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.41e-08 | 8.08e-01 | -0.00410000000000005 |
145567 | TTC7B | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.84e-10 | 4.48e-01 | -0.0179 |
145567 | TTC7B | HTA11_866_3004761011 | Human | Colorectum | AD | 5.21e-46 | 9.31e-01 | 0.096 |
145567 | TTC7B | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.88e-06 | 3.43e-01 | 0.0446 |
145567 | TTC7B | HTA11_9408_2000001011 | Human | Colorectum | AD | 5.85e-22 | 1.18e+00 | 0.0451 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
GO:00726593 | Colorectum | MSI-H | protein localization to plasma membrane | 38/1319 | 284/18723 | 1.03e-04 | 3.18e-03 | 38 |
GO:19907783 | Colorectum | MSI-H | protein localization to cell periphery | 40/1319 | 333/18723 | 6.61e-04 | 1.27e-02 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC7B | SNV | Missense_Mutation | c.811N>T | p.Arg271Trp | p.R271W | Q86TV6 | protein_coding | deleterious(0) | benign(0) | TCGA-A1-A0SQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
TTC7B | SNV | Missense_Mutation | novel | c.559N>T | p.Leu187Phe | p.L187F | Q86TV6 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
TTC7B | SNV | Missense_Mutation | rs767640360 | c.2500N>A | p.Val834Met | p.V834M | Q86TV6 | protein_coding | tolerated(0.06) | benign(0.186) | TCGA-AC-A2QH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
TTC7B | SNV | Missense_Mutation | c.425N>T | p.Ala142Val | p.A142V | Q86TV6 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TTC7B | SNV | Missense_Mutation | c.1957N>A | p.Pro653Thr | p.P653T | Q86TV6 | protein_coding | tolerated(0.39) | benign(0.194) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TTC7B | SNV | Missense_Mutation | c.2456N>C | p.Glu819Ala | p.E819A | Q86TV6 | protein_coding | deleterious(0.03) | benign(0.396) | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
TTC7B | SNV | Missense_Mutation | c.2353N>C | p.Lys785Gln | p.K785Q | Q86TV6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
TTC7B | SNV | Missense_Mutation | rs771159231 | c.236G>A | p.Arg79His | p.R79H | Q86TV6 | protein_coding | deleterious(0) | benign(0.186) | TCGA-E2-A1BC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TTC7B | SNV | Missense_Mutation | rs757702454 | c.2510N>T | p.Thr837Ile | p.T837I | Q86TV6 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC7B | SNV | Missense_Mutation | novel | c.1274N>A | p.Arg425His | p.R425H | Q86TV6 | protein_coding | tolerated(0.06) | probably_damaging(0.947) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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