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Gene: TSPAN31 |
Gene summary for TSPAN31 |
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Gene information | Species | Human | Gene symbol | TSPAN31 | Gene ID | 6302 |
Gene name | tetraspanin 31 | |
Gene Alias | SAS | |
Cytomap | 12q14.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | F8VWE0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6302 | TSPAN31 | LZE4T | Human | Esophagus | ESCC | 4.61e-03 | 1.19e-01 | 0.0811 |
6302 | TSPAN31 | LZE20T | Human | Esophagus | ESCC | 1.76e-03 | 7.32e-02 | 0.0662 |
6302 | TSPAN31 | LZE24T | Human | Esophagus | ESCC | 3.83e-15 | 4.69e-01 | 0.0596 |
6302 | TSPAN31 | P1T-E | Human | Esophagus | ESCC | 9.97e-11 | 4.86e-01 | 0.0875 |
6302 | TSPAN31 | P2T-E | Human | Esophagus | ESCC | 4.33e-33 | 6.77e-01 | 0.1177 |
6302 | TSPAN31 | P4T-E | Human | Esophagus | ESCC | 2.12e-16 | 2.90e-01 | 0.1323 |
6302 | TSPAN31 | P5T-E | Human | Esophagus | ESCC | 9.87e-18 | 2.71e-01 | 0.1327 |
6302 | TSPAN31 | P8T-E | Human | Esophagus | ESCC | 2.30e-25 | 4.10e-01 | 0.0889 |
6302 | TSPAN31 | P9T-E | Human | Esophagus | ESCC | 2.28e-10 | 1.34e-01 | 0.1131 |
6302 | TSPAN31 | P10T-E | Human | Esophagus | ESCC | 3.19e-11 | 1.58e-01 | 0.116 |
6302 | TSPAN31 | P11T-E | Human | Esophagus | ESCC | 8.28e-08 | 4.37e-01 | 0.1426 |
6302 | TSPAN31 | P12T-E | Human | Esophagus | ESCC | 3.90e-21 | 3.83e-01 | 0.1122 |
6302 | TSPAN31 | P15T-E | Human | Esophagus | ESCC | 8.19e-10 | 2.28e-01 | 0.1149 |
6302 | TSPAN31 | P16T-E | Human | Esophagus | ESCC | 1.20e-24 | 5.24e-01 | 0.1153 |
6302 | TSPAN31 | P17T-E | Human | Esophagus | ESCC | 3.86e-04 | 3.29e-01 | 0.1278 |
6302 | TSPAN31 | P19T-E | Human | Esophagus | ESCC | 1.71e-08 | 6.77e-01 | 0.1662 |
6302 | TSPAN31 | P20T-E | Human | Esophagus | ESCC | 4.82e-20 | 4.48e-01 | 0.1124 |
6302 | TSPAN31 | P21T-E | Human | Esophagus | ESCC | 1.27e-16 | 2.87e-01 | 0.1617 |
6302 | TSPAN31 | P22T-E | Human | Esophagus | ESCC | 1.07e-19 | 3.85e-01 | 0.1236 |
6302 | TSPAN31 | P23T-E | Human | Esophagus | ESCC | 1.39e-13 | 4.74e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN31 | SNV | Missense_Mutation | c.362N>G | p.Asp121Gly | p.D121G | Q12999 | protein_coding | tolerated(0.37) | benign(0.011) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TSPAN31 | insertion | In_Frame_Ins | novel | c.89_90insCCTCCCCCCAAGTCCTTGGGACCACTTGGGTCCCCAGAGCTG | p.Val30_Ala31insLeuProProSerProTrpAspHisLeuGlyProGlnSerTrp | p.V30_A31insLPPSPWDHLGPQSW | Q12999 | protein_coding | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TSPAN31 | insertion | In_Frame_Ins | novel | c.193_194insCCAGATTCTCCCCTTTCTTGTCTTTGT | p.Val65delinsAlaArgPheSerProPheLeuSerLeuLeu | p.V65delinsARFSPFLSLL | Q12999 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
TSPAN31 | SNV | Missense_Mutation | novel | c.119N>C | p.Val40Ala | p.V40A | Q12999 | protein_coding | deleterious(0) | possibly_damaging(0.689) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TSPAN31 | SNV | Missense_Mutation | novel | c.484N>A | p.Glu162Lys | p.E162K | Q12999 | protein_coding | tolerated(0.57) | benign(0.062) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
TSPAN31 | SNV | Missense_Mutation | novel | c.78N>T | p.Leu26Phe | p.L26F | Q12999 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN31 | SNV | Missense_Mutation | novel | c.424N>T | p.Asp142Tyr | p.D142Y | Q12999 | protein_coding | deleterious(0.01) | benign(0.414) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TSPAN31 | SNV | Missense_Mutation | c.293C>G | p.Ala98Gly | p.A98G | Q12999 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-G4-6299-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
TSPAN31 | SNV | Missense_Mutation | novel | c.196N>A | p.Gly66Ser | p.G66S | Q12999 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN31 | SNV | Missense_Mutation | novel | c.481G>A | p.Gly161Arg | p.G161R | Q12999 | protein_coding | tolerated(0.33) | probably_damaging(0.988) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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