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Gene: TRAPPC13 |
Gene summary for TRAPPC13 |
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Gene information | Species | Human | Gene symbol | TRAPPC13 | Gene ID | 80006 |
Gene name | trafficking protein particle complex subunit 13 | |
Gene Alias | C5orf44 | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A5PLN9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80006 | TRAPPC13 | C04 | Human | Oral cavity | OSCC | 3.08e-04 | 2.88e-01 | 0.2633 |
80006 | TRAPPC13 | C21 | Human | Oral cavity | OSCC | 3.41e-20 | 5.09e-01 | 0.2678 |
80006 | TRAPPC13 | C30 | Human | Oral cavity | OSCC | 1.43e-12 | 5.87e-01 | 0.3055 |
80006 | TRAPPC13 | C43 | Human | Oral cavity | OSCC | 2.89e-17 | 2.90e-01 | 0.1704 |
80006 | TRAPPC13 | C46 | Human | Oral cavity | OSCC | 2.89e-09 | 2.43e-01 | 0.1673 |
80006 | TRAPPC13 | C57 | Human | Oral cavity | OSCC | 3.30e-04 | 1.86e-01 | 0.1679 |
80006 | TRAPPC13 | C08 | Human | Oral cavity | OSCC | 2.74e-10 | 2.55e-01 | 0.1919 |
80006 | TRAPPC13 | LN46 | Human | Oral cavity | OSCC | 1.81e-06 | 2.92e-01 | 0.1666 |
80006 | TRAPPC13 | SYSMH2 | Human | Oral cavity | OSCC | 1.40e-06 | 1.64e-01 | 0.2326 |
80006 | TRAPPC13 | SYSMH3 | Human | Oral cavity | OSCC | 3.71e-05 | 1.88e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAPPC13 | SNV | Missense_Mutation | rs772035030 | c.707C>T | p.Thr236Met | p.T236M | A5PLN9 | protein_coding | deleterious(0.05) | benign(0.422) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRAPPC13 | SNV | Missense_Mutation | c.404A>G | p.Glu135Gly | p.E135G | A5PLN9 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRAPPC13 | SNV | Missense_Mutation | c.334C>A | p.Leu112Ile | p.L112I | A5PLN9 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-D5-5537-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TRAPPC13 | SNV | Missense_Mutation | novel | c.1160G>A | p.Gly387Asp | p.G387D | A5PLN9 | protein_coding | deleterious(0.04) | probably_damaging(0.929) | TCGA-F4-6855-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRAPPC13 | SNV | Missense_Mutation | c.913N>A | p.Asp305Asn | p.D305N | A5PLN9 | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRAPPC13 | deletion | In_Frame_Del | novel | c.628_630delAAG | p.Lys210del | p.K210del | A5PLN9 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
TRAPPC13 | SNV | Missense_Mutation | rs763269645 | c.745C>T | p.Arg249Cys | p.R249C | A5PLN9 | protein_coding | tolerated(0.21) | benign(0.218) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC13 | SNV | Missense_Mutation | novel | c.498N>G | p.Phe166Leu | p.F166L | A5PLN9 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC13 | SNV | Missense_Mutation | c.1042N>G | p.Asn348Asp | p.N348D | A5PLN9 | protein_coding | tolerated(0.56) | benign(0) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
TRAPPC13 | SNV | Missense_Mutation | c.901C>T | p.Pro301Ser | p.P301S | A5PLN9 | protein_coding | tolerated(0.13) | possibly_damaging(0.869) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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