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Gene: TMEM229B |
Gene summary for TMEM229B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM229B | Gene ID | 161145 |
| Gene name | transmembrane protein 229B | |
| Gene Alias | C14orf83 | |
| Cytomap | 14q24.1 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R699 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 161145 | TMEM229B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.22e-03 | 3.58e-01 | -0.0811 |
| 161145 | TMEM229B | HTA11_83_2000001011 | Human | Colorectum | SER | 6.06e-03 | 3.69e-01 | -0.1526 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Esophagus | ESCC |  |
| Skin | AK |  |
| Skin | SCCIS |  |
| Skin | cSCC |  |
| Thyroid | HT |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM229B | deletion | Frame_Shift_Del | novel | c.385delN | p.Leu129SerfsTer29 | p.L129Sfs*29 | Q8NBD8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| TMEM229B | SNV | Missense_Mutation | novel | c.263N>C | p.Glu88Ala | p.E88A | Q8NBD8 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM229B | SNV | Missense_Mutation | c.85G>A | p.Ala29Thr | p.A29T | Q8NBD8 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TMEM229B | deletion | Frame_Shift_Del | c.382delG | p.Ala128ProfsTer30 | p.A128Pfs*30 | Q8NBD8 | protein_coding | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
| TMEM229B | SNV | Missense_Mutation | c.203N>A | p.Arg68His | p.R68H | Q8NBD8 | protein_coding | tolerated(0.15) | benign(0.011) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
| TMEM229B | SNV | Missense_Mutation | c.124N>T | p.Pro42Ser | p.P42S | Q8NBD8 | protein_coding | tolerated(0.1) | possibly_damaging(0.531) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
| TMEM229B | SNV | Missense_Mutation | novel | c.500N>C | p.Asp167Ala | p.D167A | Q8NBD8 | protein_coding | deleterious_low_confidence(0.04) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM229B | SNV | Missense_Mutation | c.298N>A | p.Ala100Thr | p.A100T | Q8NBD8 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| TMEM229B | SNV | Missense_Mutation | novel | c.364N>A | p.Val122Met | p.V122M | Q8NBD8 | protein_coding | tolerated(0.16) | benign(0.342) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TMEM229B | SNV | Missense_Mutation | novel | c.86N>T | p.Ala29Val | p.A29V | Q8NBD8 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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