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Gene: SPATA6 |
Gene summary for SPATA6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SPATA6 | Gene ID | 54558 |
Gene name | spermatogenesis associated 6 | |
Gene Alias | HASH | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NWH7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54558 | SPATA6 | LZE24T | Human | Esophagus | ESCC | 7.61e-04 | 2.06e-01 | 0.0596 |
54558 | SPATA6 | P1T-E | Human | Esophagus | ESCC | 3.97e-06 | 2.07e-01 | 0.0875 |
54558 | SPATA6 | P2T-E | Human | Esophagus | ESCC | 3.24e-37 | 5.57e-01 | 0.1177 |
54558 | SPATA6 | P8T-E | Human | Esophagus | ESCC | 1.36e-05 | 8.15e-02 | 0.0889 |
54558 | SPATA6 | P10T-E | Human | Esophagus | ESCC | 9.05e-09 | 1.44e-01 | 0.116 |
54558 | SPATA6 | P11T-E | Human | Esophagus | ESCC | 5.38e-14 | 3.42e-01 | 0.1426 |
54558 | SPATA6 | P16T-E | Human | Esophagus | ESCC | 3.60e-10 | 1.86e-01 | 0.1153 |
54558 | SPATA6 | P19T-E | Human | Esophagus | ESCC | 3.36e-03 | 3.12e-01 | 0.1662 |
54558 | SPATA6 | P20T-E | Human | Esophagus | ESCC | 5.86e-09 | 1.44e-01 | 0.1124 |
54558 | SPATA6 | P21T-E | Human | Esophagus | ESCC | 3.46e-06 | 1.15e-01 | 0.1617 |
54558 | SPATA6 | P22T-E | Human | Esophagus | ESCC | 1.35e-04 | 7.30e-02 | 0.1236 |
54558 | SPATA6 | P24T-E | Human | Esophagus | ESCC | 7.48e-05 | 1.39e-01 | 0.1287 |
54558 | SPATA6 | P26T-E | Human | Esophagus | ESCC | 1.61e-06 | 1.18e-01 | 0.1276 |
54558 | SPATA6 | P27T-E | Human | Esophagus | ESCC | 2.41e-03 | 6.67e-02 | 0.1055 |
54558 | SPATA6 | P30T-E | Human | Esophagus | ESCC | 1.85e-04 | 9.96e-02 | 0.137 |
54558 | SPATA6 | P32T-E | Human | Esophagus | ESCC | 1.91e-05 | 1.43e-01 | 0.1666 |
54558 | SPATA6 | P36T-E | Human | Esophagus | ESCC | 6.25e-04 | 9.47e-02 | 0.1187 |
54558 | SPATA6 | P39T-E | Human | Esophagus | ESCC | 3.69e-06 | 7.77e-02 | 0.0894 |
54558 | SPATA6 | P42T-E | Human | Esophagus | ESCC | 9.10e-03 | 1.27e-01 | 0.1175 |
54558 | SPATA6 | P44T-E | Human | Esophagus | ESCC | 4.20e-06 | 1.31e-01 | 0.1096 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | |
Skin | AK | |
Skin | SCCIS | |
Skin | cSCC | |
Thyroid | HT |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA6 | SNV | Missense_Mutation | c.1378N>A | p.Pro460Thr | p.P460T | Q9NWH7 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
SPATA6 | SNV | Missense_Mutation | c.638N>T | p.Ser213Leu | p.S213L | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
SPATA6 | deletion | Frame_Shift_Del | c.135delA | p.Gln45HisfsTer25 | p.Q45Hfs*25 | Q9NWH7 | protein_coding | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SPATA6 | SNV | Missense_Mutation | novel | c.1355N>T | p.Ser452Phe | p.S452F | Q9NWH7 | protein_coding | deleterious(0.05) | benign(0.269) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
SPATA6 | SNV | Missense_Mutation | c.97C>T | p.Leu33Phe | p.L33F | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA6 | SNV | Missense_Mutation | c.107G>C | p.Cys36Ser | p.C36S | Q9NWH7 | protein_coding | tolerated(0.54) | possibly_damaging(0.891) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA6 | SNV | Missense_Mutation | rs377106164 | c.674G>A | p.Arg225His | p.R225H | Q9NWH7 | protein_coding | tolerated(0.11) | probably_damaging(0.984) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | rs201878636 | c.983N>T | p.Ser328Leu | p.S328L | Q9NWH7 | protein_coding | tolerated(0.73) | benign(0.053) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | rs755315175 | c.1279G>A | p.Glu427Lys | p.E427K | Q9NWH7 | protein_coding | tolerated(0.17) | probably_damaging(0.955) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | novel | c.538C>A | p.Gln180Lys | p.Q180K | Q9NWH7 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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