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Gene: SNX7 |
Gene summary for SNX7 |
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Gene information | Species | Human | Gene symbol | SNX7 | Gene ID | 51375 |
Gene name | sorting nexin 7 | |
Gene Alias | SNX7 | |
Cytomap | 1p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UNH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51375 | SNX7 | LZE20T | Human | Esophagus | ESCC | 8.99e-03 | 6.10e-02 | 0.0662 |
51375 | SNX7 | LZE24T | Human | Esophagus | ESCC | 2.46e-05 | 4.63e-02 | 0.0596 |
51375 | SNX7 | P1T-E | Human | Esophagus | ESCC | 1.64e-02 | 1.19e-01 | 0.0875 |
51375 | SNX7 | P2T-E | Human | Esophagus | ESCC | 1.06e-18 | 3.64e-01 | 0.1177 |
51375 | SNX7 | P4T-E | Human | Esophagus | ESCC | 7.69e-14 | 2.54e-01 | 0.1323 |
51375 | SNX7 | P5T-E | Human | Esophagus | ESCC | 1.55e-15 | 2.97e-01 | 0.1327 |
51375 | SNX7 | P8T-E | Human | Esophagus | ESCC | 6.79e-20 | 3.73e-01 | 0.0889 |
51375 | SNX7 | P9T-E | Human | Esophagus | ESCC | 8.98e-11 | 1.99e-01 | 0.1131 |
51375 | SNX7 | P10T-E | Human | Esophagus | ESCC | 4.52e-11 | 8.13e-02 | 0.116 |
51375 | SNX7 | P11T-E | Human | Esophagus | ESCC | 4.62e-11 | 2.86e-01 | 0.1426 |
51375 | SNX7 | P12T-E | Human | Esophagus | ESCC | 1.82e-14 | 2.51e-01 | 0.1122 |
51375 | SNX7 | P16T-E | Human | Esophagus | ESCC | 1.07e-02 | -4.53e-03 | 0.1153 |
51375 | SNX7 | P19T-E | Human | Esophagus | ESCC | 1.06e-08 | 6.18e-01 | 0.1662 |
51375 | SNX7 | P20T-E | Human | Esophagus | ESCC | 1.46e-11 | 9.89e-02 | 0.1124 |
51375 | SNX7 | P22T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.06e-01 | 0.1236 |
51375 | SNX7 | P23T-E | Human | Esophagus | ESCC | 2.17e-19 | 5.06e-01 | 0.108 |
51375 | SNX7 | P24T-E | Human | Esophagus | ESCC | 1.16e-10 | 2.02e-01 | 0.1287 |
51375 | SNX7 | P26T-E | Human | Esophagus | ESCC | 2.38e-17 | 2.32e-01 | 0.1276 |
51375 | SNX7 | P27T-E | Human | Esophagus | ESCC | 2.46e-13 | 5.31e-02 | 0.1055 |
51375 | SNX7 | P30T-E | Human | Esophagus | ESCC | 1.30e-09 | 3.12e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX7 | SNV | Missense_Mutation | novel | c.850N>A | p.Glu284Lys | p.E284K | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
SNX7 | SNV | Missense_Mutation | c.291C>A | p.Phe97Leu | p.F97L | Q9UNH6 | protein_coding | tolerated(0.09) | benign(0.062) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | c.287N>C | p.Leu96Pro | p.L96P | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E2-A1LL-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
SNX7 | SNV | Missense_Mutation | rs373801140 | c.514N>T | p.Arg172Cys | p.R172C | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
SNX7 | SNV | Missense_Mutation | c.607G>C | p.Asp203His | p.D203H | Q9UNH6 | protein_coding | tolerated(0.85) | benign(0.024) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD | |
SNX7 | SNV | Missense_Mutation | c.339N>A | p.Phe113Leu | p.F113L | Q9UNH6 | protein_coding | deleterious(0.01) | possibly_damaging(0.739) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | c.190N>A | p.Leu64Met | p.L64M | Q9UNH6 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.976) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SNX7 | SNV | Missense_Mutation | c.134N>C | p.Val45Ala | p.V45A | Q9UNH6 | protein_coding | tolerated_low_confidence(0.77) | probably_damaging(0.971) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
SNX7 | SNV | Missense_Mutation | c.1130N>T | p.Pro377Leu | p.P377L | Q9UNH6 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-DY-A1DD-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | novel | c.333N>C | p.Glu111Asp | p.E111D | Q9UNH6 | protein_coding | deleterious(0.03) | benign(0.283) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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