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Gene: SNED1 |
Gene summary for SNED1 |
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Gene information | Species | Human | Gene symbol | SNED1 | Gene ID | 25992 |
Gene name | sushi, nidogen and EGF like domains 1 | |
Gene Alias | IRE-BP1 | |
Cytomap | 2q37.3 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q8TER0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25992 | SNED1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-05 | -2.09e-01 | 0.0155 |
25992 | SNED1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.45e-03 | -2.09e-01 | -0.1088 |
25992 | SNED1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.95e-04 | -2.04e-01 | -0.1954 |
25992 | SNED1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.20e-03 | -2.01e-01 | -0.1464 |
25992 | SNED1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.04e-05 | -2.09e-01 | -0.1001 |
25992 | SNED1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.56e-02 | -2.02e-01 | -0.059 |
25992 | SNED1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.41e-02 | -1.96e-01 | 0.096 |
25992 | SNED1 | A001-C-108 | Human | Colorectum | FAP | 2.13e-10 | 4.65e-01 | -0.0272 |
25992 | SNED1 | A002-C-021 | Human | Colorectum | FAP | 1.85e-15 | 5.60e-01 | 0.1171 |
25992 | SNED1 | A001-C-104 | Human | Colorectum | FAP | 2.03e-03 | 3.84e-01 | 0.0184 |
25992 | SNED1 | A015-C-106 | Human | Colorectum | FAP | 1.52e-08 | 4.93e-01 | -0.0511 |
25992 | SNED1 | A001-C-014 | Human | Colorectum | FAP | 5.22e-12 | 6.02e-01 | 0.0135 |
25992 | SNED1 | A001-C-203 | Human | Colorectum | FAP | 3.37e-02 | 3.14e-01 | -0.0481 |
25992 | SNED1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.34e-06 | 8.15e-01 | 0.3385 |
25992 | SNED1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.67e-02 | 5.73e-01 | 0.3329 |
25992 | SNED1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.16e-17 | 7.71e-01 | -0.2116 |
25992 | SNED1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 9.11e-06 | 7.00e-01 | -0.1941 |
25992 | SNED1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.78e-05 | 6.46e-01 | -0.2107 |
25992 | SNED1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.78e-13 | 6.81e-01 | -0.2119 |
25992 | SNED1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 2.31e-04 | 9.57e-01 | -0.0296 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:00315893 | Colorectum | FAP | cell-substrate adhesion | 93/2622 | 363/18723 | 2.48e-09 | 4.61e-07 | 93 |
GO:00071603 | Colorectum | FAP | cell-matrix adhesion | 63/2622 | 233/18723 | 1.13e-07 | 7.43e-06 | 63 |
GO:00071607 | Lung | IAC | cell-matrix adhesion | 63/2061 | 233/18723 | 7.08e-12 | 4.27e-09 | 63 |
GO:00315897 | Lung | IAC | cell-substrate adhesion | 85/2061 | 363/18723 | 8.57e-12 | 4.27e-09 | 85 |
GO:000716012 | Lung | AIS | cell-matrix adhesion | 60/1849 | 233/18723 | 2.19e-12 | 2.55e-09 | 60 |
GO:003158913 | Lung | AIS | cell-substrate adhesion | 80/1849 | 363/18723 | 3.80e-12 | 3.16e-09 | 80 |
GO:000716031 | Lung | MIAC | cell-matrix adhesion | 35/967 | 233/18723 | 1.26e-08 | 7.17e-06 | 35 |
GO:003158931 | Lung | MIAC | cell-substrate adhesion | 44/967 | 363/18723 | 1.30e-07 | 3.56e-05 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNED1 | SNV | Missense_Mutation | c.1546G>C | p.Asp516His | p.D516H | Q8TER0 | protein_coding | tolerated(0.07) | probably_damaging(1) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
SNED1 | SNV | Missense_Mutation | c.1874N>G | p.Ser625Cys | p.S625C | Q8TER0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SNED1 | SNV | Missense_Mutation | rs544068694 | c.2017N>A | p.Glu673Lys | p.E673K | Q8TER0 | protein_coding | tolerated(0.42) | benign(0.038) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SNED1 | SNV | Missense_Mutation | novel | c.902N>G | p.Ser301Trp | p.S301W | Q8TER0 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SNED1 | SNV | Missense_Mutation | rs373616563 | c.2912N>T | p.Ala971Val | p.A971V | Q8TER0 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-BH-A0DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
SNED1 | SNV | Missense_Mutation | c.283N>A | p.Ala95Thr | p.A95T | Q8TER0 | protein_coding | tolerated(0.06) | benign(0.355) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
SNED1 | deletion | Frame_Shift_Del | novel | c.1875delN | p.Gly626AlafsTer31 | p.G626Afs*31 | Q8TER0 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SNED1 | SNV | Missense_Mutation | novel | c.3961N>G | p.Thr1321Ala | p.T1321A | Q8TER0 | protein_coding | deleterious(0.01) | benign(0.198) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SNED1 | SNV | Missense_Mutation | novel | c.3056N>A | p.Ser1019Asn | p.S1019N | Q8TER0 | protein_coding | tolerated(0.12) | benign(0.058) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
SNED1 | SNV | Missense_Mutation | c.2218C>A | p.Gln740Lys | p.Q740K | Q8TER0 | protein_coding | tolerated(0.37) | benign(0.079) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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