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Gene: SMIM13 |
Gene summary for SMIM13 |
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Gene information | Species | Human | Gene symbol | SMIM13 | Gene ID | 221710 |
Gene name | small integral membrane protein 13 | |
Gene Alias | C6orf228 | |
Cytomap | 6p24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P0DJ93 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221710 | SMIM13 | LZE7T | Human | Esophagus | ESCC | 4.12e-02 | 1.57e-01 | 0.0667 |
221710 | SMIM13 | LZE24T | Human | Esophagus | ESCC | 4.84e-02 | 1.32e-01 | 0.0596 |
221710 | SMIM13 | P1T-E | Human | Esophagus | ESCC | 1.80e-02 | 9.51e-02 | 0.0875 |
221710 | SMIM13 | P2T-E | Human | Esophagus | ESCC | 6.67e-10 | 2.04e-01 | 0.1177 |
221710 | SMIM13 | P4T-E | Human | Esophagus | ESCC | 3.74e-14 | 4.73e-01 | 0.1323 |
221710 | SMIM13 | P5T-E | Human | Esophagus | ESCC | 3.68e-17 | 3.08e-01 | 0.1327 |
221710 | SMIM13 | P8T-E | Human | Esophagus | ESCC | 4.22e-11 | 7.75e-02 | 0.0889 |
221710 | SMIM13 | P9T-E | Human | Esophagus | ESCC | 1.29e-08 | 2.91e-01 | 0.1131 |
221710 | SMIM13 | P10T-E | Human | Esophagus | ESCC | 6.33e-07 | 1.21e-02 | 0.116 |
221710 | SMIM13 | P11T-E | Human | Esophagus | ESCC | 3.19e-11 | 5.68e-01 | 0.1426 |
221710 | SMIM13 | P12T-E | Human | Esophagus | ESCC | 1.64e-07 | 2.47e-01 | 0.1122 |
221710 | SMIM13 | P15T-E | Human | Esophagus | ESCC | 9.57e-12 | 2.73e-01 | 0.1149 |
221710 | SMIM13 | P16T-E | Human | Esophagus | ESCC | 5.38e-11 | 2.03e-02 | 0.1153 |
221710 | SMIM13 | P19T-E | Human | Esophagus | ESCC | 1.75e-02 | 3.36e-01 | 0.1662 |
221710 | SMIM13 | P21T-E | Human | Esophagus | ESCC | 2.05e-13 | 2.52e-01 | 0.1617 |
221710 | SMIM13 | P22T-E | Human | Esophagus | ESCC | 1.74e-07 | 2.56e-02 | 0.1236 |
221710 | SMIM13 | P23T-E | Human | Esophagus | ESCC | 1.34e-06 | 2.73e-01 | 0.108 |
221710 | SMIM13 | P24T-E | Human | Esophagus | ESCC | 2.33e-06 | 2.02e-01 | 0.1287 |
221710 | SMIM13 | P26T-E | Human | Esophagus | ESCC | 1.45e-17 | 2.58e-01 | 0.1276 |
221710 | SMIM13 | P27T-E | Human | Esophagus | ESCC | 2.23e-04 | 1.82e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM13 | deletion | Frame_Shift_Del | novel | c.16delN | p.Leu7Ter | p.L7* | P0DJ93 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SMIM13 | insertion | Frame_Shift_Ins | novel | c.97_98insT | p.Leu35PhefsTer22 | p.L35Ffs*22 | P0DJ93 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SMIM13 | SNV | Missense_Mutation | novel | c.121N>A | p.Leu41Ile | p.L41I | P0DJ93 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM13 | SNV | Missense_Mutation | novel | c.56N>C | p.Val19Ala | p.V19A | P0DJ93 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM13 | SNV | Missense_Mutation | novel | c.199N>C | p.Ser67Pro | p.S67P | P0DJ93 | protein_coding | tolerated(1) | benign(0) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMIM13 | SNV | Missense_Mutation | novel | c.56T>C | p.Val19Ala | p.V19A | P0DJ93 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SMIM13 | insertion | Frame_Shift_Ins | novel | c.97_98insT | p.Leu35PhefsTer22 | p.L35Ffs*22 | P0DJ93 | protein_coding | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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