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Gene: SLC7A7 |
Gene summary for SLC7A7 |
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Gene information | Species | Human | Gene symbol | SLC7A7 | Gene ID | 9056 |
Gene name | solute carrier family 7 member 7 | |
Gene Alias | LAT3 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000820 | UniProtAcc | A0A0S2Z502 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9056 | SLC7A7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.58e-03 | 2.72e-01 | -0.1808 |
9056 | SLC7A7 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.45e-06 | 3.84e-01 | -0.1526 |
9056 | SLC7A7 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.76e-03 | 3.23e-01 | 0.0131 |
9056 | SLC7A7 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.23e-02 | 3.79e-01 | 0.0397 |
9056 | SLC7A7 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.18e-19 | 6.72e-01 | 0.0588 |
9056 | SLC7A7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.39e-22 | 5.09e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
GO:00620121 | Colorectum | MSS | regulation of small molecule metabolic process | 83/3467 | 334/18723 | 2.25e-03 | 1.85e-02 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A7 | SNV | Missense_Mutation | rs763715975 | c.1210N>T | p.Arg404Cys | p.R404C | Q9UM01 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A7 | SNV | Missense_Mutation | c.737N>C | p.Asn246Thr | p.N246T | Q9UM01 | protein_coding | deleterious(0.03) | possibly_damaging(0.789) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
SLC7A7 | insertion | Nonsense_Mutation | novel | c.1102_1103insAGGGACTATGACAAAGCACTTTATTTAGAAACCTTT | p.Met368delinsLysGlyLeuTerGlnSerThrLeuPheArgAsnLeuLeu | p.M368delinsKGL*QSTLFRNLL | Q9UM01 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC7A7 | insertion | Frame_Shift_Ins | novel | c.1369_1370insCA | p.Tyr457SerfsTer63 | p.Y457Sfs*63 | Q9UM01 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC7A7 | deletion | Frame_Shift_Del | c.516delT | p.Asn173ThrfsTer23 | p.N173Tfs*23 | Q9UM01 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SLC7A7 | SNV | Missense_Mutation | rs780597284 | c.590C>T | p.Ala197Val | p.A197V | Q9UM01 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A7 | SNV | Missense_Mutation | rs752725969 | c.1213N>C | p.Trp405Arg | p.W405R | Q9UM01 | protein_coding | deleterious(0.03) | possibly_damaging(0.905) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A7 | SNV | Missense_Mutation | c.1270T>G | p.Phe424Val | p.F424V | Q9UM01 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A7 | SNV | Missense_Mutation | novel | c.286A>G | p.Thr96Ala | p.T96A | Q9UM01 | protein_coding | deleterious(0.05) | probably_damaging(0.964) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A7 | SNV | Missense_Mutation | novel | c.1319C>A | p.Thr440Asn | p.T440N | Q9UM01 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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