![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SELENOH |
Gene summary for SELENOH |
![]() |
Gene information | Species | Human | Gene symbol | SELENOH | Gene ID | 280636 |
Gene name | selenoprotein H | |
Gene Alias | C11orf31 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IZQ5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
280636 | SELENOH | GSM4909281 | Human | Breast | IDC | 7.85e-34 | 7.33e-01 | 0.21 |
280636 | SELENOH | GSM4909285 | Human | Breast | IDC | 2.50e-13 | 2.04e-01 | 0.21 |
280636 | SELENOH | GSM4909286 | Human | Breast | IDC | 2.08e-15 | 2.75e-01 | 0.1081 |
280636 | SELENOH | GSM4909290 | Human | Breast | IDC | 3.81e-14 | 5.49e-01 | 0.2096 |
280636 | SELENOH | GSM4909291 | Human | Breast | IDC | 1.81e-11 | 5.34e-01 | 0.1753 |
280636 | SELENOH | GSM4909293 | Human | Breast | IDC | 7.27e-08 | 5.20e-02 | 0.1581 |
280636 | SELENOH | GSM4909294 | Human | Breast | IDC | 1.42e-04 | 2.34e-01 | 0.2022 |
280636 | SELENOH | GSM4909295 | Human | Breast | IDC | 3.16e-03 | 3.97e-01 | 0.0898 |
280636 | SELENOH | GSM4909296 | Human | Breast | IDC | 1.91e-17 | 5.34e-01 | 0.1524 |
280636 | SELENOH | GSM4909297 | Human | Breast | IDC | 3.97e-10 | 1.79e-01 | 0.1517 |
280636 | SELENOH | GSM4909298 | Human | Breast | IDC | 1.24e-10 | 3.37e-01 | 0.1551 |
280636 | SELENOH | GSM4909299 | Human | Breast | IDC | 5.12e-12 | 3.60e-01 | 0.035 |
280636 | SELENOH | GSM4909301 | Human | Breast | IDC | 1.72e-20 | 6.01e-01 | 0.1577 |
280636 | SELENOH | GSM4909302 | Human | Breast | IDC | 7.99e-15 | 5.22e-01 | 0.1545 |
280636 | SELENOH | GSM4909304 | Human | Breast | IDC | 3.30e-07 | 3.45e-01 | 0.1636 |
280636 | SELENOH | GSM4909305 | Human | Breast | IDC | 5.09e-15 | 5.19e-01 | 0.0436 |
280636 | SELENOH | GSM4909306 | Human | Breast | IDC | 9.95e-31 | 7.27e-01 | 0.1564 |
280636 | SELENOH | GSM4909307 | Human | Breast | IDC | 4.39e-39 | 8.09e-01 | 0.1569 |
280636 | SELENOH | GSM4909308 | Human | Breast | IDC | 1.93e-47 | 8.33e-01 | 0.158 |
280636 | SELENOH | GSM4909309 | Human | Breast | IDC | 2.54e-10 | 4.60e-01 | 0.0483 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SELENOH | SNV | Missense_Mutation | c.85G>C | p.Glu29Gln | p.E29Q | Q8IZQ5 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SELENOH | SNV | Missense_Mutation | c.334G>C | p.Glu112Gln | p.E112Q | Q8IZQ5 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-G4-6627-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SELENOH | SNV | Missense_Mutation | novel | c.34N>A | p.Ala12Thr | p.A12T | Q8IZQ5 | protein_coding | deleterious(0.05) | benign(0.326) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SELENOH | SNV | Missense_Mutation | novel | c.287N>T | p.Gly96Val | p.G96V | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
SELENOH | SNV | Missense_Mutation | novel | c.121N>C | p.Cys41Arg | p.C41R | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SELENOH | SNV | Missense_Mutation | novel | c.351N>T | p.Leu117Phe | p.L117F | Q8IZQ5 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SELENOH | SNV | Missense_Mutation | novel | c.224G>A | p.Arg75Gln | p.R75Q | Q8IZQ5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |