Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
GO:000020915 | Oral cavity | LP | protein polyubiquitination | 82/4623 | 236/18723 | 3.23e-04 | 3.26e-03 | 82 |
GO:000020914 | Prostate | Tumor | protein polyubiquitination | 64/3246 | 236/18723 | 1.08e-04 | 1.03e-03 | 64 |
GO:000020924 | Skin | cSCC | protein polyubiquitination | 103/4864 | 236/18723 | 2.57e-09 | 9.09e-08 | 103 |
GO:000020920 | Thyroid | PTC | protein polyubiquitination | 128/5968 | 236/18723 | 7.81e-13 | 3.65e-11 | 128 |
GO:0000209110 | Thyroid | ATC | protein polyubiquitination | 134/6293 | 236/18723 | 1.86e-13 | 9.20e-12 | 134 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUSC1 | SNV | Missense_Mutation | novel | c.939N>G | p.Ile313Met | p.I313M | Q9BVN2 | protein_coding | deleterious_low_confidence(0) | benign(0.144) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD |
RUSC1 | SNV | Missense_Mutation | novel | c.2614C>T | p.Arg872Cys | p.R872C | Q9BVN2 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUSC1 | SNV | Missense_Mutation | | c.1906G>A | p.Ala636Thr | p.A636T | Q9BVN2 | protein_coding | deleterious(0.04) | probably_damaging(0.93) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUSC1 | insertion | Nonsense_Mutation | novel | c.973_974insCCTGGCCTAGAATCAGTTCTTAACCCTAGCAGCACCCTAGTTTCACCT | p.Arg325delinsProTrpProArgIleSerSerTerProTerGlnHisProSerPheThrTrp | p.R325delinsPWPRISS*P*QHPSFTW | Q9BVN2 | protein_coding | | | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
RUSC1 | insertion | In_Frame_Ins | novel | c.2615_2616insGCTCTTTAATGGCTTGAGATACTCTCTAGTGGCCAT | p.Arg872_Val873insLeuPheAsnGlyLeuArgTyrSerLeuValAlaIle | p.R872_V873insLFNGLRYSLVAI | Q9BVN2 | protein_coding | | | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUSC1 | insertion | Frame_Shift_Ins | novel | c.1039_1040insGCAGCCAGCAGATG | p.Ser347CysfsTer79 | p.S347Cfs*79 | Q9BVN2 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUSC1 | insertion | Nonsense_Mutation | novel | c.1041_1042insGAGTTGACAAGCTGACGGCTGCT | p.Pro348GlufsTer5 | p.P348Efs*5 | Q9BVN2 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUSC1 | SNV | Missense_Mutation | | c.321N>G | p.Ser107Arg | p.S107R | Q9BVN2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.942) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RUSC1 | SNV | Missense_Mutation | | c.323N>T | p.Ser108Phe | p.S108F | Q9BVN2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.694) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RUSC1 | SNV | Missense_Mutation | novel | c.380N>G | p.Pro127Arg | p.P127R | Q9BVN2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.942) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |