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Gene: RSBN1 |
Gene summary for RSBN1 |
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Gene information | Species | Human | Gene symbol | RSBN1 | Gene ID | 54665 |
Gene name | round spermatid basic protein 1 | |
Gene Alias | KDM9 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006325 | UniProtAcc | Q5VWQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54665 | RSBN1 | LZE4T | Human | Esophagus | ESCC | 3.81e-12 | 4.25e-01 | 0.0811 |
54665 | RSBN1 | LZE7T | Human | Esophagus | ESCC | 3.00e-11 | 6.82e-01 | 0.0667 |
54665 | RSBN1 | LZE8T | Human | Esophagus | ESCC | 6.01e-06 | 1.26e-01 | 0.067 |
54665 | RSBN1 | LZE20T | Human | Esophagus | ESCC | 7.72e-03 | 1.53e-01 | 0.0662 |
54665 | RSBN1 | LZE22D1 | Human | Esophagus | HGIN | 1.70e-03 | 9.06e-02 | 0.0595 |
54665 | RSBN1 | LZE24T | Human | Esophagus | ESCC | 7.16e-16 | 2.01e-01 | 0.0596 |
54665 | RSBN1 | LZE21T | Human | Esophagus | ESCC | 4.54e-03 | 1.48e-01 | 0.0655 |
54665 | RSBN1 | LZE6T | Human | Esophagus | ESCC | 1.20e-05 | 1.07e-01 | 0.0845 |
54665 | RSBN1 | P1T-E | Human | Esophagus | ESCC | 5.06e-08 | 4.42e-01 | 0.0875 |
54665 | RSBN1 | P2T-E | Human | Esophagus | ESCC | 6.05e-29 | 6.09e-01 | 0.1177 |
54665 | RSBN1 | P4T-E | Human | Esophagus | ESCC | 6.25e-21 | 4.36e-01 | 0.1323 |
54665 | RSBN1 | P5T-E | Human | Esophagus | ESCC | 1.07e-14 | 2.05e-01 | 0.1327 |
54665 | RSBN1 | P8T-E | Human | Esophagus | ESCC | 1.65e-20 | 3.25e-01 | 0.0889 |
54665 | RSBN1 | P9T-E | Human | Esophagus | ESCC | 6.53e-14 | 2.10e-01 | 0.1131 |
54665 | RSBN1 | P10T-E | Human | Esophagus | ESCC | 3.79e-36 | 6.59e-01 | 0.116 |
54665 | RSBN1 | P11T-E | Human | Esophagus | ESCC | 7.53e-14 | 5.66e-01 | 0.1426 |
54665 | RSBN1 | P12T-E | Human | Esophagus | ESCC | 5.84e-67 | 1.41e+00 | 0.1122 |
54665 | RSBN1 | P15T-E | Human | Esophagus | ESCC | 5.74e-08 | 1.97e-01 | 0.1149 |
54665 | RSBN1 | P16T-E | Human | Esophagus | ESCC | 2.35e-25 | 3.21e-01 | 0.1153 |
54665 | RSBN1 | P17T-E | Human | Esophagus | ESCC | 2.53e-07 | 3.41e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:000632521 | Oral cavity | NEOLP | chromatin organization | 70/2005 | 409/18723 | 4.97e-05 | 6.83e-04 | 70 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSBN1 | SNV | Missense_Mutation | c.787N>G | p.Arg263Gly | p.R263G | Q5VWQ0 | protein_coding | deleterious_low_confidence(0) | benign(0.203) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RSBN1 | SNV | Missense_Mutation | novel | c.1665G>T | p.Met555Ile | p.M555I | Q5VWQ0 | protein_coding | tolerated(0.23) | benign(0.35) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RSBN1 | SNV | Missense_Mutation | c.1194N>C | p.Leu398Phe | p.L398F | Q5VWQ0 | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
RSBN1 | SNV | Missense_Mutation | novel | c.2332N>T | p.Pro778Ser | p.P778S | Q5VWQ0 | protein_coding | deleterious_low_confidence(0.01) | benign(0.021) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSBN1 | SNV | Missense_Mutation | rs750349807 | c.809N>A | p.Arg270His | p.R270H | Q5VWQ0 | protein_coding | deleterious_low_confidence(0.04) | benign(0.005) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSBN1 | SNV | Missense_Mutation | c.925N>C | p.Phe309Leu | p.F309L | Q5VWQ0 | protein_coding | tolerated_low_confidence(0.44) | benign(0.303) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
RSBN1 | SNV | Missense_Mutation | c.2110N>A | p.Tyr704Asn | p.Y704N | Q5VWQ0 | protein_coding | deleterious(0) | benign(0.005) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
RSBN1 | insertion | Nonsense_Mutation | novel | c.570_571insGTCTCTCTCAGTTCCGATATCCCGCATCTTTAGGACTGAAAGA | p.Arg191ValfsTer11 | p.R191Vfs*11 | Q5VWQ0 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RSBN1 | deletion | Frame_Shift_Del | novel | c.760delA | p.Ile254Ter | p.I254* | Q5VWQ0 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
RSBN1 | SNV | Missense_Mutation | c.1841G>A | p.Arg614His | p.R614H | Q5VWQ0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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