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Gene: RAET1L |
Gene summary for RAET1L |
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Gene information | Species | Human | Gene symbol | RAET1L | Gene ID | 154064 |
Gene name | retinoic acid early transcript 1L | |
Gene Alias | ULBP6 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q5VY80 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
154064 | RAET1L | LZE4T | Human | Esophagus | ESCC | 1.20e-05 | 2.59e-01 | 0.0811 |
154064 | RAET1L | LZE7T | Human | Esophagus | ESCC | 2.99e-07 | 3.14e-01 | 0.0667 |
154064 | RAET1L | LZE8T | Human | Esophagus | ESCC | 8.14e-07 | 2.44e-01 | 0.067 |
154064 | RAET1L | LZE22T | Human | Esophagus | ESCC | 1.27e-03 | 4.94e-01 | 0.068 |
154064 | RAET1L | LZE24T | Human | Esophagus | ESCC | 1.35e-03 | 3.15e-01 | 0.0596 |
154064 | RAET1L | LZE21T | Human | Esophagus | ESCC | 4.36e-09 | 7.55e-01 | 0.0655 |
154064 | RAET1L | P4T-E | Human | Esophagus | ESCC | 2.40e-21 | 6.13e-01 | 0.1323 |
154064 | RAET1L | P5T-E | Human | Esophagus | ESCC | 6.74e-42 | 8.00e-01 | 0.1327 |
154064 | RAET1L | P8T-E | Human | Esophagus | ESCC | 3.97e-03 | 1.45e-01 | 0.0889 |
154064 | RAET1L | P9T-E | Human | Esophagus | ESCC | 1.87e-08 | 2.88e-01 | 0.1131 |
154064 | RAET1L | P11T-E | Human | Esophagus | ESCC | 3.19e-03 | 1.10e-01 | 0.1426 |
154064 | RAET1L | P12T-E | Human | Esophagus | ESCC | 2.88e-26 | 6.88e-01 | 0.1122 |
154064 | RAET1L | P15T-E | Human | Esophagus | ESCC | 2.73e-13 | 4.46e-01 | 0.1149 |
154064 | RAET1L | P21T-E | Human | Esophagus | ESCC | 1.14e-14 | 3.61e-01 | 0.1617 |
154064 | RAET1L | P22T-E | Human | Esophagus | ESCC | 9.41e-06 | 7.72e-02 | 0.1236 |
154064 | RAET1L | P23T-E | Human | Esophagus | ESCC | 1.59e-07 | 2.35e-01 | 0.108 |
154064 | RAET1L | P26T-E | Human | Esophagus | ESCC | 1.61e-35 | 6.65e-01 | 0.1276 |
154064 | RAET1L | P27T-E | Human | Esophagus | ESCC | 2.93e-15 | 3.13e-01 | 0.1055 |
154064 | RAET1L | P28T-E | Human | Esophagus | ESCC | 1.16e-43 | 9.24e-01 | 0.1149 |
154064 | RAET1L | P30T-E | Human | Esophagus | ESCC | 5.49e-04 | 1.40e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAET1L | SNV | Missense_Mutation | novel | c.541T>C | p.Ser181Pro | p.S181P | Q5VY80 | protein_coding | deleterious(0.03) | benign(0.106) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RAET1L | SNV | Missense_Mutation | c.454N>C | p.Asp152His | p.D152H | Q5VY80 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RAET1L | SNV | Missense_Mutation | c.591N>A | p.Phe197Leu | p.F197L | Q5VY80 | protein_coding | deleterious(0.01) | possibly_damaging(0.832) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RAET1L | SNV | Missense_Mutation | rs527453577 | c.143G>A | p.Arg48Gln | p.R48Q | Q5VY80 | protein_coding | tolerated(0.55) | benign(0.011) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
RAET1L | SNV | Missense_Mutation | rs772532524 | c.179N>T | p.Thr60Ile | p.T60I | Q5VY80 | protein_coding | tolerated(0.42) | benign(0.021) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RAET1L | SNV | Missense_Mutation | novel | c.631G>T | p.Ala211Ser | p.A211S | Q5VY80 | protein_coding | tolerated(0.44) | benign(0.156) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAET1L | SNV | Missense_Mutation | rs148747435 | c.530A>T | p.Asp177Val | p.D177V | Q5VY80 | protein_coding | tolerated(0.45) | benign(0.022) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAET1L | SNV | Missense_Mutation | c.196N>C | p.Cys66Arg | p.C66R | Q5VY80 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A0VZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
RAET1L | SNV | Missense_Mutation | novel | c.177N>T | p.Lys59Asn | p.K59N | Q5VY80 | protein_coding | tolerated(0.26) | benign(0.081) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAET1L | SNV | Missense_Mutation | novel | c.293N>C | p.Val98Ala | p.V98A | Q5VY80 | protein_coding | tolerated(0.68) | benign(0.14) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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