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Gene: PRR15L |
Gene summary for PRR15L |
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Gene information | Species | Human | Gene symbol | PRR15L | Gene ID | 79170 |
Gene name | proline rich 15 like | |
Gene Alias | ATAD4 | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A140VJT1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79170 | PRR15L | GSM4909298 | Human | Breast | IDC | 6.55e-11 | 2.94e-01 | 0.1551 |
79170 | PRR15L | GSM4909302 | Human | Breast | IDC | 8.36e-04 | 2.84e-01 | 0.1545 |
79170 | PRR15L | GSM4909305 | Human | Breast | IDC | 6.11e-06 | 3.00e-01 | 0.0436 |
79170 | PRR15L | GSM4909306 | Human | Breast | IDC | 1.68e-05 | 2.35e-01 | 0.1564 |
79170 | PRR15L | GSM4909312 | Human | Breast | IDC | 2.22e-08 | 2.86e-01 | 0.1552 |
79170 | PRR15L | GSM4909317 | Human | Breast | IDC | 6.22e-04 | 2.30e-01 | 0.1355 |
79170 | PRR15L | M5 | Human | Breast | IDC | 3.17e-05 | 6.57e-01 | 0.1598 |
79170 | PRR15L | DCIS2 | Human | Breast | DCIS | 2.52e-19 | 1.54e-01 | 0.0085 |
79170 | PRR15L | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.61e-16 | 6.41e-01 | -0.1808 |
79170 | PRR15L | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.18e-08 | 4.88e-01 | -0.0811 |
79170 | PRR15L | HTA11_78_2000001011 | Human | Colorectum | AD | 2.81e-10 | 4.49e-01 | -0.1088 |
79170 | PRR15L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.35e-31 | 7.45e-01 | -0.1954 |
79170 | PRR15L | HTA11_411_2000001011 | Human | Colorectum | SER | 1.82e-09 | 1.10e+00 | -0.2602 |
79170 | PRR15L | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.38e-03 | 7.42e-01 | -0.2196 |
79170 | PRR15L | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.66e-03 | 3.92e-01 | -0.1207 |
79170 | PRR15L | HTA11_83_2000001011 | Human | Colorectum | SER | 9.37e-03 | 3.69e-01 | -0.1526 |
79170 | PRR15L | HTA11_696_2000001011 | Human | Colorectum | AD | 4.52e-15 | 5.70e-01 | -0.1464 |
79170 | PRR15L | HTA11_866_2000001011 | Human | Colorectum | AD | 5.50e-04 | 2.04e-01 | -0.1001 |
79170 | PRR15L | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.03e-07 | 4.35e-01 | -0.059 |
79170 | PRR15L | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.77e-06 | 7.30e-01 | -0.1706 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR15L | insertion | Frame_Shift_Ins | novel | c.100_101insGGATTAGAGTCCTAGAAGTAAAAGAGAA | p.Glu34GlyfsTer19 | p.E34Gfs*19 | Q9BU68 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
PRR15L | SNV | Missense_Mutation | c.185N>A | p.Ser62Asn | p.S62N | Q9BU68 | protein_coding | tolerated(0.83) | benign(0.001) | TCGA-G5-6235-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | PD | |
PRR15L | SNV | Missense_Mutation | novel | c.296G>A | p.Gly99Glu | p.G99E | Q9BU68 | protein_coding | deleterious_low_confidence(0.04) | benign(0.015) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRR15L | SNV | Missense_Mutation | rs774458737 | c.146N>A | p.Ser49Asn | p.S49N | Q9BU68 | protein_coding | tolerated_low_confidence(0.44) | benign(0.015) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRR15L | SNV | Missense_Mutation | c.151N>G | p.Phe51Val | p.F51V | Q9BU68 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRR15L | SNV | Missense_Mutation | c.171G>T | p.Lys57Asn | p.K57N | Q9BU68 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PRR15L | SNV | Missense_Mutation | novel | c.226T>C | p.Phe76Leu | p.F76L | Q9BU68 | protein_coding | deleterious(0) | possibly_damaging(0.592) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PRR15L | SNV | Missense_Mutation | novel | c.82N>A | p.Asp28Asn | p.D28N | Q9BU68 | protein_coding | tolerated(0.28) | benign(0.3) | TCGA-QS-A5YQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
PRR15L | SNV | Missense_Mutation | novel | c.175N>A | p.Val59Met | p.V59M | Q9BU68 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRR15L | SNV | Missense_Mutation | novel | c.35N>A | p.Phe12Tyr | p.F12Y | Q9BU68 | protein_coding | deleterious(0.02) | possibly_damaging(0.673) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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