![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PNMA1 |
Gene summary for PNMA1 |
![]() |
Gene information | Species | Human | Gene symbol | PNMA1 | Gene ID | 9240 |
Gene name | PNMA family member 1 | |
Gene Alias | MA1 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8ND90 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9240 | PNMA1 | LZE20T | Human | Esophagus | ESCC | 4.29e-02 | 1.56e-01 | 0.0662 |
9240 | PNMA1 | LZE24T | Human | Esophagus | ESCC | 9.92e-10 | 3.13e-01 | 0.0596 |
9240 | PNMA1 | P2T-E | Human | Esophagus | ESCC | 9.46e-13 | 2.22e-01 | 0.1177 |
9240 | PNMA1 | P4T-E | Human | Esophagus | ESCC | 7.62e-13 | 4.18e-01 | 0.1323 |
9240 | PNMA1 | P5T-E | Human | Esophagus | ESCC | 1.61e-12 | 2.43e-01 | 0.1327 |
9240 | PNMA1 | P8T-E | Human | Esophagus | ESCC | 1.18e-19 | 3.26e-01 | 0.0889 |
9240 | PNMA1 | P9T-E | Human | Esophagus | ESCC | 3.30e-09 | 1.34e-01 | 0.1131 |
9240 | PNMA1 | P10T-E | Human | Esophagus | ESCC | 1.63e-19 | 3.74e-01 | 0.116 |
9240 | PNMA1 | P11T-E | Human | Esophagus | ESCC | 2.97e-13 | 5.88e-01 | 0.1426 |
9240 | PNMA1 | P12T-E | Human | Esophagus | ESCC | 3.50e-52 | 9.00e-01 | 0.1122 |
9240 | PNMA1 | P15T-E | Human | Esophagus | ESCC | 3.94e-32 | 7.41e-01 | 0.1149 |
9240 | PNMA1 | P16T-E | Human | Esophagus | ESCC | 4.71e-31 | 5.52e-01 | 0.1153 |
9240 | PNMA1 | P17T-E | Human | Esophagus | ESCC | 1.96e-08 | 5.56e-01 | 0.1278 |
9240 | PNMA1 | P19T-E | Human | Esophagus | ESCC | 1.44e-10 | 6.80e-01 | 0.1662 |
9240 | PNMA1 | P20T-E | Human | Esophagus | ESCC | 1.52e-05 | 1.42e-01 | 0.1124 |
9240 | PNMA1 | P21T-E | Human | Esophagus | ESCC | 6.32e-15 | 3.08e-01 | 0.1617 |
9240 | PNMA1 | P22T-E | Human | Esophagus | ESCC | 2.34e-07 | 1.48e-01 | 0.1236 |
9240 | PNMA1 | P23T-E | Human | Esophagus | ESCC | 2.57e-10 | 1.80e-01 | 0.108 |
9240 | PNMA1 | P24T-E | Human | Esophagus | ESCC | 5.95e-27 | 5.65e-01 | 0.1287 |
9240 | PNMA1 | P26T-E | Human | Esophagus | ESCC | 9.59e-10 | 2.28e-01 | 0.1276 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNMA1 | SNV | Missense_Mutation | novel | c.647N>G | p.Ile216Ser | p.I216S | Q8ND90 | protein_coding | deleterious(0) | benign(0.399) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PNMA1 | SNV | Missense_Mutation | novel | c.859A>G | p.Asn287Asp | p.N287D | Q8ND90 | protein_coding | tolerated(1) | benign(0.117) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PNMA1 | SNV | Missense_Mutation | c.602N>A | p.Arg201Gln | p.R201Q | Q8ND90 | protein_coding | tolerated(0.08) | probably_damaging(0.97) | TCGA-BH-A1EO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PNMA1 | insertion | Frame_Shift_Ins | novel | c.833_834insTAGGGCTACCAGCCTTATTAAATCCTTTGGATTGGGGGAT | p.Lys278AsnfsTer18 | p.K278Nfs*18 | Q8ND90 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PNMA1 | insertion | Frame_Shift_Ins | novel | c.645_646insTGGGCAACAGAGTG | p.Ile216TrpfsTer5 | p.I216Wfs*5 | Q8ND90 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PNMA1 | SNV | Missense_Mutation | novel | c.700G>C | p.Glu234Gln | p.E234Q | Q8ND90 | protein_coding | tolerated(0.06) | benign(0.19) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PNMA1 | SNV | Missense_Mutation | c.868N>T | p.Arg290Cys | p.R290C | Q8ND90 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PNMA1 | SNV | Missense_Mutation | c.389N>T | p.Pro130Leu | p.P130L | Q8ND90 | protein_coding | tolerated(0.43) | benign(0.011) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PNMA1 | SNV | Missense_Mutation | c.224N>G | p.Ala75Gly | p.A75G | Q8ND90 | protein_coding | deleterious(0.03) | benign(0.127) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PNMA1 | SNV | Missense_Mutation | c.226N>A | p.Ala76Thr | p.A76T | Q8ND90 | protein_coding | tolerated(0.48) | benign(0.01) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |