![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PHLDB3 |
Gene summary for PHLDB3 |
![]() |
Gene information | Species | Human | Gene symbol | PHLDB3 | Gene ID | 653583 |
Gene name | pleckstrin homology like domain family B member 3 | |
Gene Alias | PHLDB3 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6NSJ2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
653583 | PHLDB3 | LZE4T | Human | Esophagus | ESCC | 1.58e-05 | 2.91e-01 | 0.0811 |
653583 | PHLDB3 | LZE7T | Human | Esophagus | ESCC | 1.93e-04 | 2.58e-01 | 0.0667 |
653583 | PHLDB3 | LZE20T | Human | Esophagus | ESCC | 2.99e-04 | 2.55e-01 | 0.0662 |
653583 | PHLDB3 | LZE22T | Human | Esophagus | ESCC | 3.93e-03 | 4.64e-01 | 0.068 |
653583 | PHLDB3 | LZE24T | Human | Esophagus | ESCC | 3.72e-12 | 3.04e-01 | 0.0596 |
653583 | PHLDB3 | LZE21T | Human | Esophagus | ESCC | 2.32e-05 | 3.61e-01 | 0.0655 |
653583 | PHLDB3 | P1T-E | Human | Esophagus | ESCC | 1.06e-08 | 4.37e-01 | 0.0875 |
653583 | PHLDB3 | P2T-E | Human | Esophagus | ESCC | 3.57e-16 | 3.17e-01 | 0.1177 |
653583 | PHLDB3 | P4T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.49e-01 | 0.1323 |
653583 | PHLDB3 | P5T-E | Human | Esophagus | ESCC | 2.67e-16 | 3.19e-01 | 0.1327 |
653583 | PHLDB3 | P8T-E | Human | Esophagus | ESCC | 3.56e-29 | 4.45e-01 | 0.0889 |
653583 | PHLDB3 | P9T-E | Human | Esophagus | ESCC | 3.59e-05 | 1.82e-01 | 0.1131 |
653583 | PHLDB3 | P10T-E | Human | Esophagus | ESCC | 8.77e-17 | 2.77e-01 | 0.116 |
653583 | PHLDB3 | P11T-E | Human | Esophagus | ESCC | 5.00e-17 | 4.88e-01 | 0.1426 |
653583 | PHLDB3 | P12T-E | Human | Esophagus | ESCC | 3.25e-40 | 6.23e-01 | 0.1122 |
653583 | PHLDB3 | P15T-E | Human | Esophagus | ESCC | 8.19e-19 | 4.22e-01 | 0.1149 |
653583 | PHLDB3 | P16T-E | Human | Esophagus | ESCC | 4.36e-06 | 1.16e-01 | 0.1153 |
653583 | PHLDB3 | P20T-E | Human | Esophagus | ESCC | 1.60e-12 | 3.10e-01 | 0.1124 |
653583 | PHLDB3 | P21T-E | Human | Esophagus | ESCC | 6.61e-11 | 2.16e-01 | 0.1617 |
653583 | PHLDB3 | P22T-E | Human | Esophagus | ESCC | 2.00e-15 | 3.84e-01 | 0.1236 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHLDB3 | SNV | Missense_Mutation | novel | c.245N>A | p.Ala82Asp | p.A82D | Q6NSJ2 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-A7-A13H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | PD |
PHLDB3 | SNV | Missense_Mutation | c.298C>T | p.Arg100Cys | p.R100C | Q6NSJ2 | protein_coding | deleterious(0.05) | probably_damaging(0.991) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PHLDB3 | SNV | Missense_Mutation | rs759214501 | c.692N>A | p.Arg231His | p.R231H | Q6NSJ2 | protein_coding | tolerated(0.14) | benign(0.022) | TCGA-B6-A402-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PD |
PHLDB3 | SNV | Missense_Mutation | c.266C>G | p.Ser89Cys | p.S89C | Q6NSJ2 | protein_coding | tolerated(0.11) | benign(0.124) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHLDB3 | SNV | Missense_Mutation | c.490N>A | p.Gln164Lys | p.Q164K | Q6NSJ2 | protein_coding | tolerated(0.86) | benign(0.035) | TCGA-E2-A1IL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PHLDB3 | SNV | Missense_Mutation | c.1812C>G | p.Phe604Leu | p.F604L | Q6NSJ2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PHLDB3 | SNV | Missense_Mutation | novel | c.208G>A | p.Asp70Asn | p.D70N | Q6NSJ2 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
PHLDB3 | SNV | Missense_Mutation | rs200179651 | c.1634N>A | p.Arg545His | p.R545H | Q6NSJ2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
PHLDB3 | SNV | Missense_Mutation | novel | c.535G>A | p.Glu179Lys | p.E179K | Q6NSJ2 | protein_coding | deleterious(0.01) | probably_damaging(0.968) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PHLDB3 | SNV | Missense_Mutation | c.1554N>T | p.Trp518Cys | p.W518C | Q6NSJ2 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |