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Gene: PDPR |
Gene summary for PDPR |
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Gene information | Species | Human | Gene symbol | PDPR | Gene ID | 55066 |
Gene name | pyruvate dehydrogenase phosphatase regulatory subunit | |
Gene Alias | PDP3 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NCN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55066 | PDPR | LZE4T | Human | Esophagus | ESCC | 3.37e-02 | 1.04e-01 | 0.0811 |
55066 | PDPR | LZE7T | Human | Esophagus | ESCC | 1.46e-05 | 1.85e-01 | 0.0667 |
55066 | PDPR | LZE8T | Human | Esophagus | ESCC | 3.97e-02 | 3.41e-02 | 0.067 |
55066 | PDPR | LZE24T | Human | Esophagus | ESCC | 4.09e-11 | 1.80e-01 | 0.0596 |
55066 | PDPR | P1T-E | Human | Esophagus | ESCC | 5.08e-08 | 4.86e-01 | 0.0875 |
55066 | PDPR | P2T-E | Human | Esophagus | ESCC | 5.03e-11 | -9.27e-04 | 0.1177 |
55066 | PDPR | P4T-E | Human | Esophagus | ESCC | 8.03e-06 | 8.44e-02 | 0.1323 |
55066 | PDPR | P5T-E | Human | Esophagus | ESCC | 2.81e-21 | 6.99e-02 | 0.1327 |
55066 | PDPR | P8T-E | Human | Esophagus | ESCC | 6.87e-10 | 1.42e-01 | 0.0889 |
55066 | PDPR | P10T-E | Human | Esophagus | ESCC | 4.29e-13 | 1.77e-01 | 0.116 |
55066 | PDPR | P11T-E | Human | Esophagus | ESCC | 8.33e-11 | 2.37e-01 | 0.1426 |
55066 | PDPR | P12T-E | Human | Esophagus | ESCC | 1.52e-08 | -1.86e-03 | 0.1122 |
55066 | PDPR | P15T-E | Human | Esophagus | ESCC | 4.31e-14 | 3.26e-01 | 0.1149 |
55066 | PDPR | P16T-E | Human | Esophagus | ESCC | 3.46e-12 | 6.15e-02 | 0.1153 |
55066 | PDPR | P20T-E | Human | Esophagus | ESCC | 2.80e-07 | 7.88e-02 | 0.1124 |
55066 | PDPR | P21T-E | Human | Esophagus | ESCC | 2.35e-24 | 1.87e-01 | 0.1617 |
55066 | PDPR | P22T-E | Human | Esophagus | ESCC | 2.96e-13 | 2.90e-02 | 0.1236 |
55066 | PDPR | P23T-E | Human | Esophagus | ESCC | 3.57e-11 | 1.57e-01 | 0.108 |
55066 | PDPR | P24T-E | Human | Esophagus | ESCC | 5.51e-07 | -1.35e-02 | 0.1287 |
55066 | PDPR | P26T-E | Human | Esophagus | ESCC | 5.50e-22 | 1.56e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDPR | SNV | Missense_Mutation | rs201382204 | c.2296N>T | p.Arg766Cys | p.R766C | Q8NCN5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDPR | SNV | Missense_Mutation | c.916G>C | p.Glu306Gln | p.E306Q | Q8NCN5 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
PDPR | SNV | Missense_Mutation | c.475N>G | p.Pro159Ala | p.P159A | Q8NCN5 | protein_coding | tolerated(0.07) | benign(0.136) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
PDPR | SNV | Missense_Mutation | novel | c.798N>G | p.Phe266Leu | p.F266L | Q8NCN5 | protein_coding | tolerated(0.07) | possibly_damaging(0.665) | TCGA-LQ-A4E4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | PD |
PDPR | insertion | In_Frame_Ins | novel | c.2596_2597insCCTCCTGCAGCAGAA | p.Arg866delinsProSerCysSerArgSer | p.R866delinsPSCSRS | Q8NCN5 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PDPR | SNV | Missense_Mutation | rs763473565 | c.1730G>A | p.Ser577Asn | p.S577N | Q8NCN5 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDPR | SNV | Missense_Mutation | novel | c.2230G>A | p.Glu744Lys | p.E744K | Q8NCN5 | protein_coding | tolerated(0.09) | benign(0) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDPR | SNV | Missense_Mutation | c.2338N>C | p.Asp780His | p.D780H | Q8NCN5 | protein_coding | deleterious(0.02) | possibly_damaging(0.81) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
PDPR | SNV | Missense_Mutation | rs774671288 | c.925C>G | p.Pro309Ala | p.P309A | Q8NCN5 | protein_coding | tolerated(1) | benign(0.036) | TCGA-Q1-A73Q-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PDPR | SNV | Missense_Mutation | c.1259T>G | p.Phe420Cys | p.F420C | Q8NCN5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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