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Gene: MRPL10 |
Gene summary for MRPL10 |
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Gene information | Species | Human | Gene symbol | MRPL10 | Gene ID | 124995 |
Gene name | mitochondrial ribosomal protein L10 | |
Gene Alias | L10MT | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q7Z7H8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
124995 | MRPL10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.02e-04 | 2.84e-01 | -0.1808 |
124995 | MRPL10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.41e-02 | 1.74e-01 | -0.0811 |
124995 | MRPL10 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-03 | 1.63e-01 | -0.1954 |
124995 | MRPL10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.76e-03 | 2.22e-01 | -0.1207 |
124995 | MRPL10 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.72e-03 | 2.05e-01 | -0.1464 |
124995 | MRPL10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.83e-08 | 2.56e-01 | -0.059 |
124995 | MRPL10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.91e-03 | 2.64e-01 | -0.0179 |
124995 | MRPL10 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.22e-09 | 3.32e-01 | 0.096 |
124995 | MRPL10 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.10e-03 | 3.39e-01 | 0.0446 |
124995 | MRPL10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.98e-06 | 3.42e-01 | 0.0528 |
124995 | MRPL10 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.34e-03 | 3.84e-01 | 0.0131 |
124995 | MRPL10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.28e-02 | 3.35e-01 | 0.0171 |
124995 | MRPL10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.28e-07 | 2.34e-01 | 0.0338 |
124995 | MRPL10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.80e-14 | 2.98e-01 | 0.0674 |
124995 | MRPL10 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.26e-03 | 2.07e-01 | 0.0588 |
124995 | MRPL10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.59e-16 | 4.06e-01 | 0.294 |
124995 | MRPL10 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.35e-08 | 3.16e-01 | 0.281 |
124995 | MRPL10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.34e-19 | 5.00e-01 | 0.3859 |
124995 | MRPL10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.50e-16 | 4.06e-01 | 0.3005 |
124995 | MRPL10 | LZE4T | Human | Esophagus | ESCC | 2.25e-15 | 3.77e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL10 | SNV | Missense_Mutation | rs368901192 | c.754N>A | p.Glu252Lys | p.E252K | Q7Z7H8 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
MRPL10 | SNV | Missense_Mutation | c.520N>C | p.Met174Leu | p.M174L | Q7Z7H8 | protein_coding | tolerated(0.36) | benign(0.059) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MRPL10 | SNV | Missense_Mutation | c.568N>G | p.Cys190Gly | p.C190G | Q7Z7H8 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MRPL10 | SNV | Missense_Mutation | c.170N>G | p.Leu57Arg | p.L57R | Q7Z7H8 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL10 | SNV | Missense_Mutation | rs373997600 | c.139N>T | p.Arg47Cys | p.R47C | Q7Z7H8 | protein_coding | deleterious(0.01) | possibly_damaging(0.732) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL10 | SNV | Missense_Mutation | novel | c.230C>A | p.Ser77Tyr | p.S77Y | Q7Z7H8 | protein_coding | deleterious(0) | possibly_damaging(0.558) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MRPL10 | SNV | Missense_Mutation | c.151C>T | p.His51Tyr | p.H51Y | Q7Z7H8 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-BG-A0M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL10 | SNV | Missense_Mutation | rs781472477 | c.752N>A | p.Arg251His | p.R251H | Q7Z7H8 | protein_coding | tolerated(0.42) | benign(0) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL10 | SNV | Missense_Mutation | c.553C>T | p.Pro185Ser | p.P185S | Q7Z7H8 | protein_coding | tolerated(0.82) | benign(0.009) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPL10 | SNV | Missense_Mutation | rs369022041 | c.278N>A | p.Arg93His | p.R93H | Q7Z7H8 | protein_coding | tolerated(0.22) | benign(0.028) | TCGA-D1-A1O7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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