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Gene: MROH8 |
Gene summary for MROH8 |
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Gene information | Species | Human | Gene symbol | MROH8 | Gene ID | 140699 |
Gene name | maestro heat like repeat family member 8 | |
Gene Alias | C20orf131 | |
Cytomap | 20q11.23 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q0P682 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140699 | MROH8 | ATC13 | Human | Thyroid | ATC | 4.87e-10 | 6.31e-01 | 0.34 |
140699 | MROH8 | ATC5 | Human | Thyroid | ATC | 9.38e-16 | 6.82e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MROH8 | SNV | Missense_Mutation | novel | c.3055N>G | p.Glu1019Gly | p.E1019G | protein_coding | deleterious(0.02) | probably_damaging(0.944) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
MROH8 | SNV | Missense_Mutation | rs764466787 | c.775N>A | p.Arg259His | p.R259H | protein_coding | tolerated(0.06) | benign(0.046) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
MROH8 | SNV | Missense_Mutation | c.2333G>C | p.Lys778Asn | p.K778N | protein_coding | deleterious(0) | benign(0.373) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
MROH8 | SNV | Missense_Mutation | c.2499G>A | p.Glu834Lys | p.E834K | protein_coding | tolerated(0.12) | probably_damaging(0.919) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MROH8 | SNV | Missense_Mutation | rs759428520 | c.1510N>A | p.Arg504Gln | p.R504Q | protein_coding | tolerated(1) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MROH8 | SNV | Missense_Mutation | rs769537714 | c.3108N>A | p.Ala1037Thr | p.A1037T | protein_coding | deleterious(0.04) | benign(0.11) | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
MROH8 | SNV | Missense_Mutation | c.3120N>G | p.Leu1041Val | p.L1041V | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-D8-A1JF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
MROH8 | SNV | Missense_Mutation | c.3202N>G | p.Ser1068Cys | p.S1068C | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.634) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MROH8 | SNV | Missense_Mutation | novel | c.1683N>A | p.Asp562Asn | p.D562N | protein_coding | tolerated(0.06) | possibly_damaging(0.7) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
MROH8 | deletion | Frame_Shift_Del | novel | c.534delN | p.Asp179ThrfsTer11 | p.D179Tfs*11 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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