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Gene: MRE11 |
Gene summary for MRE11 |
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Gene information | Species | Human | Gene symbol | MRE11 | Gene ID | 4361 |
Gene name | MRE11 homolog, double strand break repair nuclease | |
Gene Alias | ATLD | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | F8W7U8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4361 | MRE11 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 6.52e-01 | 0.082 |
4361 | MRE11 | LZE4T | Human | Esophagus | ESCC | 9.66e-09 | 2.52e-01 | 0.0811 |
4361 | MRE11 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 1.95e-01 | 0.0667 |
4361 | MRE11 | LZE8T | Human | Esophagus | ESCC | 6.71e-04 | 1.67e-01 | 0.067 |
4361 | MRE11 | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 1.31e-01 | 0.0662 |
4361 | MRE11 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 2.28e-01 | 0.0632 |
4361 | MRE11 | LZE24T | Human | Esophagus | ESCC | 2.62e-15 | 3.30e-01 | 0.0596 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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