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Gene: MOB3C |
Gene summary for MOB3C |
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Gene information | Species | Human | Gene symbol | MOB3C | Gene ID | 148932 |
Gene name | MOB kinase activator 3C | |
Gene Alias | MOB1E | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | X6R3L3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148932 | MOB3C | LZE4T | Human | Esophagus | ESCC | 6.29e-06 | 1.77e-01 | 0.0811 |
148932 | MOB3C | LZE24T | Human | Esophagus | ESCC | 2.57e-02 | 1.37e-01 | 0.0596 |
148932 | MOB3C | P1T-E | Human | Esophagus | ESCC | 2.63e-03 | 2.03e-01 | 0.0875 |
148932 | MOB3C | P2T-E | Human | Esophagus | ESCC | 4.21e-10 | 1.74e-01 | 0.1177 |
148932 | MOB3C | P4T-E | Human | Esophagus | ESCC | 1.45e-05 | 7.49e-02 | 0.1323 |
148932 | MOB3C | P5T-E | Human | Esophagus | ESCC | 3.71e-04 | 8.11e-02 | 0.1327 |
148932 | MOB3C | P8T-E | Human | Esophagus | ESCC | 2.59e-05 | 5.60e-02 | 0.0889 |
148932 | MOB3C | P9T-E | Human | Esophagus | ESCC | 2.30e-09 | 1.40e-01 | 0.1131 |
148932 | MOB3C | P10T-E | Human | Esophagus | ESCC | 4.00e-09 | 6.70e-02 | 0.116 |
148932 | MOB3C | P11T-E | Human | Esophagus | ESCC | 1.00e-04 | 1.91e-01 | 0.1426 |
148932 | MOB3C | P12T-E | Human | Esophagus | ESCC | 5.01e-07 | 8.98e-02 | 0.1122 |
148932 | MOB3C | P15T-E | Human | Esophagus | ESCC | 1.64e-02 | 5.98e-02 | 0.1149 |
148932 | MOB3C | P17T-E | Human | Esophagus | ESCC | 8.29e-06 | 1.94e-01 | 0.1278 |
148932 | MOB3C | P20T-E | Human | Esophagus | ESCC | 1.96e-10 | 2.33e-01 | 0.1124 |
148932 | MOB3C | P21T-E | Human | Esophagus | ESCC | 1.47e-13 | 2.92e-01 | 0.1617 |
148932 | MOB3C | P22T-E | Human | Esophagus | ESCC | 3.70e-10 | 4.88e-02 | 0.1236 |
148932 | MOB3C | P23T-E | Human | Esophagus | ESCC | 6.56e-19 | 3.99e-01 | 0.108 |
148932 | MOB3C | P24T-E | Human | Esophagus | ESCC | 2.83e-04 | 5.80e-02 | 0.1287 |
148932 | MOB3C | P26T-E | Human | Esophagus | ESCC | 4.08e-09 | 1.51e-01 | 0.1276 |
148932 | MOB3C | P27T-E | Human | Esophagus | ESCC | 2.61e-09 | 2.07e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOB3C | SNV | Missense_Mutation | c.466N>T | p.Arg156Cys | p.R156C | protein_coding | deleterious(0.05) | possibly_damaging(0.707) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | ||
MOB3C | SNV | Missense_Mutation | novel | c.602A>T | p.Gln201Leu | p.Q201L | protein_coding | tolerated(0.09) | possibly_damaging(0.596) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MOB3C | insertion | Frame_Shift_Ins | novel | c.603_604insCTCTTCT | p.Val202LeufsTer25 | p.V202Lfs*25 | protein_coding | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MOB3C | SNV | Missense_Mutation | c.394N>A | p.Glu132Lys | p.E132K | protein_coding | deleterious(0) | possibly_damaging(0.727) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
MOB3C | SNV | Missense_Mutation | c.394N>C | p.Glu132Gln | p.E132Q | protein_coding | deleterious(0.03) | possibly_damaging(0.846) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
MOB3C | SNV | Missense_Mutation | c.65N>A | p.Arg22Lys | p.R22K | protein_coding | deleterious_low_confidence(0) | benign(0.025) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
MOB3C | SNV | Missense_Mutation | novel | c.615G>T | p.Lys205Asn | p.K205N | protein_coding | tolerated(0.22) | probably_damaging(0.948) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MOB3C | SNV | Missense_Mutation | c.398G>A | p.Arg133His | p.R133H | protein_coding | tolerated(0.1) | benign(0) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MOB3C | SNV | Missense_Mutation | c.398N>A | p.Arg133His | p.R133H | protein_coding | tolerated(0.1) | benign(0) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MOB3C | SNV | Missense_Mutation | c.289C>T | p.Arg97Cys | p.R97C | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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