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Gene: MATN3 |
Gene summary for MATN3 |
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Gene information | Species | Human | Gene symbol | MATN3 | Gene ID | 4148 |
Gene name | matrilin 3 | |
Gene Alias | DIPOA | |
Cytomap | 2p24.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | O15232 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4148 | MATN3 | HCC1_Meng | Human | Liver | HCC | 1.07e-08 | 3.84e-02 | 0.0246 |
4148 | MATN3 | S014 | Human | Liver | HCC | 9.77e-20 | 8.21e-01 | 0.2254 |
4148 | MATN3 | S015 | Human | Liver | HCC | 1.17e-24 | 1.07e+00 | 0.2375 |
4148 | MATN3 | S016 | Human | Liver | HCC | 3.00e-20 | 9.93e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MATN3 | SNV | Missense_Mutation | c.320N>G | p.Ser107Cys | p.S107C | O15232 | protein_coding | tolerated(0.09) | possibly_damaging(0.907) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
MATN3 | SNV | Missense_Mutation | c.509N>C | p.Met170Thr | p.M170T | O15232 | protein_coding | deleterious(0.02) | probably_damaging(0.912) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MATN3 | SNV | Missense_Mutation | rs563628955 | c.349N>T | p.Pro117Ser | p.P117S | O15232 | protein_coding | tolerated(0.29) | benign(0.031) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MATN3 | SNV | Missense_Mutation | c.400G>A | p.Glu134Lys | p.E134K | O15232 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MATN3 | SNV | Missense_Mutation | c.1155A>T | p.Lys385Asn | p.K385N | O15232 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MATN3 | SNV | Missense_Mutation | novel | c.767N>T | p.Ser256Phe | p.S256F | O15232 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD |
MATN3 | SNV | Missense_Mutation | rs376404727 | c.862N>T | p.His288Tyr | p.H288Y | O15232 | protein_coding | tolerated(1) | benign(0.006) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MATN3 | SNV | Missense_Mutation | rs145597203 | c.511N>A | p.Asp171Asn | p.D171N | O15232 | protein_coding | tolerated(1) | benign(0.207) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MATN3 | SNV | Missense_Mutation | novel | c.448G>A | p.Val150Met | p.V150M | O15232 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MATN3 | SNV | Missense_Mutation | c.634G>T | p.Ala212Ser | p.A212S | O15232 | protein_coding | tolerated(0.39) | possibly_damaging(0.871) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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