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Gene: LINC00662 |
Gene summary for LINC00662 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LINC00662 | Gene ID | 148189 |
Gene name | long intergenic non-protein coding RNA 662 | |
Gene Alias | LINC00662 | |
Cytomap | 19q11 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148189 | LINC00662 | LZE4T | Human | Esophagus | ESCC | 5.49e-06 | 2.17e-01 | 0.0811 |
148189 | LINC00662 | LZE5T | Human | Esophagus | ESCC | 9.00e-04 | 3.81e-01 | 0.0514 |
148189 | LINC00662 | LZE7T | Human | Esophagus | ESCC | 1.20e-04 | 3.96e-01 | 0.0667 |
148189 | LINC00662 | P1T-E | Human | Esophagus | ESCC | 1.87e-03 | 2.79e-01 | 0.0875 |
148189 | LINC00662 | P2T-E | Human | Esophagus | ESCC | 1.96e-14 | 2.69e-01 | 0.1177 |
148189 | LINC00662 | P4T-E | Human | Esophagus | ESCC | 8.93e-15 | 3.58e-01 | 0.1323 |
148189 | LINC00662 | P5T-E | Human | Esophagus | ESCC | 1.39e-11 | 3.31e-01 | 0.1327 |
148189 | LINC00662 | P8T-E | Human | Esophagus | ESCC | 3.07e-25 | 4.49e-01 | 0.0889 |
148189 | LINC00662 | P9T-E | Human | Esophagus | ESCC | 6.01e-11 | 3.10e-01 | 0.1131 |
148189 | LINC00662 | P10T-E | Human | Esophagus | ESCC | 4.90e-58 | 9.36e-01 | 0.116 |
148189 | LINC00662 | P11T-E | Human | Esophagus | ESCC | 5.28e-13 | 4.68e-01 | 0.1426 |
148189 | LINC00662 | P12T-E | Human | Esophagus | ESCC | 1.09e-22 | 4.21e-01 | 0.1122 |
148189 | LINC00662 | P16T-E | Human | Esophagus | ESCC | 1.61e-16 | 3.07e-01 | 0.1153 |
148189 | LINC00662 | P17T-E | Human | Esophagus | ESCC | 2.52e-04 | 2.50e-01 | 0.1278 |
148189 | LINC00662 | P19T-E | Human | Esophagus | ESCC | 8.02e-05 | 3.41e-01 | 0.1662 |
148189 | LINC00662 | P20T-E | Human | Esophagus | ESCC | 5.93e-07 | 1.98e-01 | 0.1124 |
148189 | LINC00662 | P21T-E | Human | Esophagus | ESCC | 2.14e-09 | 1.73e-01 | 0.1617 |
148189 | LINC00662 | P22T-E | Human | Esophagus | ESCC | 1.36e-29 | 5.92e-01 | 0.1236 |
148189 | LINC00662 | P23T-E | Human | Esophagus | ESCC | 1.55e-03 | 1.44e-01 | 0.108 |
148189 | LINC00662 | P24T-E | Human | Esophagus | ESCC | 1.92e-07 | 1.67e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | |
Skin | AK | |
Skin | SCCIS | |
Skin | cSCC | |
Thyroid | HT |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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