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Gene: KIAA1586 |
Gene summary for KIAA1586 |
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Gene information | Species | Human | Gene symbol | KIAA1586 | Gene ID | 57691 |
Gene name | KIAA1586 | |
Gene Alias | KIAA1586 | |
Cytomap | 6p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4DIC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57691 | KIAA1586 | LZE4T | Human | Esophagus | ESCC | 1.10e-05 | 9.64e-02 | 0.0811 |
57691 | KIAA1586 | LZE7T | Human | Esophagus | ESCC | 6.73e-06 | 3.85e-01 | 0.0667 |
57691 | KIAA1586 | LZE24T | Human | Esophagus | ESCC | 4.09e-08 | 1.04e-01 | 0.0596 |
57691 | KIAA1586 | P1T-E | Human | Esophagus | ESCC | 1.97e-06 | 2.14e-01 | 0.0875 |
57691 | KIAA1586 | P2T-E | Human | Esophagus | ESCC | 8.83e-13 | 2.55e-01 | 0.1177 |
57691 | KIAA1586 | P4T-E | Human | Esophagus | ESCC | 1.37e-16 | 3.75e-01 | 0.1323 |
57691 | KIAA1586 | P5T-E | Human | Esophagus | ESCC | 1.29e-08 | 1.14e-01 | 0.1327 |
57691 | KIAA1586 | P8T-E | Human | Esophagus | ESCC | 1.24e-11 | 1.68e-01 | 0.0889 |
57691 | KIAA1586 | P9T-E | Human | Esophagus | ESCC | 2.12e-16 | 2.45e-01 | 0.1131 |
57691 | KIAA1586 | P10T-E | Human | Esophagus | ESCC | 4.74e-13 | 2.15e-01 | 0.116 |
57691 | KIAA1586 | P11T-E | Human | Esophagus | ESCC | 3.63e-10 | 4.69e-01 | 0.1426 |
57691 | KIAA1586 | P12T-E | Human | Esophagus | ESCC | 6.39e-18 | 2.79e-01 | 0.1122 |
57691 | KIAA1586 | P15T-E | Human | Esophagus | ESCC | 4.03e-04 | 4.79e-02 | 0.1149 |
57691 | KIAA1586 | P16T-E | Human | Esophagus | ESCC | 5.81e-24 | 4.55e-01 | 0.1153 |
57691 | KIAA1586 | P17T-E | Human | Esophagus | ESCC | 9.12e-11 | 3.84e-01 | 0.1278 |
57691 | KIAA1586 | P19T-E | Human | Esophagus | ESCC | 8.47e-04 | 2.05e-01 | 0.1662 |
57691 | KIAA1586 | P20T-E | Human | Esophagus | ESCC | 1.27e-13 | 1.93e-01 | 0.1124 |
57691 | KIAA1586 | P21T-E | Human | Esophagus | ESCC | 4.98e-16 | 2.36e-01 | 0.1617 |
57691 | KIAA1586 | P22T-E | Human | Esophagus | ESCC | 2.51e-19 | 3.12e-01 | 0.1236 |
57691 | KIAA1586 | P23T-E | Human | Esophagus | ESCC | 3.09e-07 | 1.62e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001692512 | Esophagus | ESCC | protein sumoylation | 41/8552 | 53/18723 | 2.49e-06 | 2.86e-05 | 41 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:0016925 | Liver | HCC | protein sumoylation | 34/7958 | 53/18723 | 1.20e-03 | 6.68e-03 | 34 |
GO:00182059 | Thyroid | PTC | peptidyl-lysine modification | 188/5968 | 376/18723 | 1.34e-13 | 7.09e-12 | 188 |
GO:00169256 | Thyroid | PTC | protein sumoylation | 30/5968 | 53/18723 | 1.71e-04 | 1.31e-03 | 30 |
GO:001820516 | Thyroid | ATC | peptidyl-lysine modification | 193/6293 | 376/18723 | 6.92e-13 | 3.06e-11 | 193 |
GO:001692513 | Thyroid | ATC | protein sumoylation | 30/6293 | 53/18723 | 4.84e-04 | 2.83e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1586 | SNV | Missense_Mutation | c.1840N>C | p.Met614Leu | p.M614L | Q9HCI6 | protein_coding | tolerated(0.24) | benign(0.042) | TCGA-AN-A0AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIAA1586 | SNV | Missense_Mutation | rs754494794 | c.929N>G | p.Glu310Gly | p.E310G | Q9HCI6 | protein_coding | tolerated(0.18) | benign(0.098) | TCGA-BH-A18S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1586 | insertion | Nonsense_Mutation | novel | c.1982_1983insGAGCCACTGCTCCCAGCCCCTTTGCCCGTTTTGTTTCTAATTA | p.Ile661MetfsTer14 | p.I661Mfs*14 | Q9HCI6 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
KIAA1586 | deletion | Frame_Shift_Del | c.821delN | p.Asn276MetfsTer4 | p.N276Mfs*4 | Q9HCI6 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
KIAA1586 | SNV | Missense_Mutation | novel | c.836T>C | p.Val279Ala | p.V279A | Q9HCI6 | protein_coding | tolerated(0.48) | benign(0.086) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KIAA1586 | SNV | Missense_Mutation | c.811N>A | p.Glu271Lys | p.E271K | Q9HCI6 | protein_coding | tolerated(0.21) | possibly_damaging(0.763) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA1586 | SNV | Missense_Mutation | c.128N>A | p.Leu43His | p.L43H | Q9HCI6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA1586 | SNV | Missense_Mutation | c.139G>A | p.Asp47Asn | p.D47N | Q9HCI6 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.914) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIAA1586 | SNV | Missense_Mutation | novel | c.1627T>A | p.Leu543Ile | p.L543I | Q9HCI6 | protein_coding | deleterious(0.01) | possibly_damaging(0.843) | TCGA-AA-A024-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1586 | SNV | Missense_Mutation | c.139N>A | p.Asp47Asn | p.D47N | Q9HCI6 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.914) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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