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Gene: HSD17B13 |
Gene summary for HSD17B13 |
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Gene information | Species | Human | Gene symbol | HSD17B13 | Gene ID | 345275 |
Gene name | hydroxysteroid 17-beta dehydrogenase 13 | |
Gene Alias | HMFN0376 | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q7Z5P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
345275 | HSD17B13 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.82e-06 | 5.84e-01 | 0.1633 |
345275 | HSD17B13 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 4.07e-05 | 5.45e-01 | 0.1602 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00192166 | Prostate | Tumor | regulation of lipid metabolic process | 76/3246 | 331/18723 | 5.04e-03 | 2.45e-02 | 76 |
GO:00468905 | Prostate | Tumor | regulation of lipid biosynthetic process | 42/3246 | 171/18723 | 1.02e-02 | 4.28e-02 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD17B13 | SNV | Missense_Mutation | c.253N>A | p.Val85Ile | p.V85I | Q7Z5P4 | protein_coding | deleterious(0.01) | benign(0.244) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |
HSD17B13 | SNV | Missense_Mutation | c.590G>A | p.Arg197Lys | p.R197K | Q7Z5P4 | protein_coding | tolerated(0.56) | benign(0.009) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSD17B13 | SNV | Missense_Mutation | c.408N>T | p.Glu136Asp | p.E136D | Q7Z5P4 | protein_coding | tolerated(0.34) | benign(0.034) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HSD17B13 | SNV | Missense_Mutation | novel | c.768N>T | p.Met256Ile | p.M256I | Q7Z5P4 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HSD17B13 | SNV | Missense_Mutation | rs779627733 | c.382G>A | p.Asp128Asn | p.D128N | Q7Z5P4 | protein_coding | tolerated(0.13) | possibly_damaging(0.761) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
HSD17B13 | SNV | Missense_Mutation | c.580G>A | p.Gly194Ser | p.G194S | Q7Z5P4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD17B13 | deletion | In_Frame_Del | c.24_26delNNN | p.Leu11del | p.L11del | Q7Z5P4 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
HSD17B13 | SNV | Missense_Mutation | novel | c.592G>T | p.Gly198Cys | p.G198C | Q7Z5P4 | protein_coding | deleterious(0) | benign(0.038) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HSD17B13 | SNV | Missense_Mutation | c.472N>C | p.Ser158Pro | p.S158P | Q7Z5P4 | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
HSD17B13 | SNV | Missense_Mutation | rs779627733 | c.382N>A | p.Asp128Asn | p.D128N | Q7Z5P4 | protein_coding | tolerated(0.13) | possibly_damaging(0.761) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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