![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FUBP3 |
Gene summary for FUBP3 |
![]() |
Gene information | Species | Human | Gene symbol | FUBP3 | Gene ID | 8939 |
Gene name | far upstream element binding protein 3 | |
Gene Alias | FBP3 | |
Cytomap | 9q34.11-q34.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R8A7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8939 | FUBP3 | CCI_2 | Human | Cervix | CC | 2.06e-07 | 8.94e-01 | 0.5249 |
8939 | FUBP3 | CCI_3 | Human | Cervix | CC | 1.37e-08 | 5.33e-01 | 0.516 |
8939 | FUBP3 | LZE4T | Human | Esophagus | ESCC | 1.18e-03 | 5.38e-02 | 0.0811 |
8939 | FUBP3 | LZE8T | Human | Esophagus | ESCC | 4.35e-02 | 1.28e-02 | 0.067 |
8939 | FUBP3 | LZE20T | Human | Esophagus | ESCC | 9.17e-04 | 1.42e-01 | 0.0662 |
8939 | FUBP3 | LZE24T | Human | Esophagus | ESCC | 1.45e-09 | 2.15e-01 | 0.0596 |
8939 | FUBP3 | LZE21T | Human | Esophagus | ESCC | 1.60e-02 | 9.80e-02 | 0.0655 |
8939 | FUBP3 | P2T-E | Human | Esophagus | ESCC | 1.48e-24 | 3.95e-01 | 0.1177 |
8939 | FUBP3 | P4T-E | Human | Esophagus | ESCC | 7.47e-19 | 3.40e-01 | 0.1323 |
8939 | FUBP3 | P5T-E | Human | Esophagus | ESCC | 4.47e-20 | 1.62e-01 | 0.1327 |
8939 | FUBP3 | P8T-E | Human | Esophagus | ESCC | 5.13e-25 | 5.10e-01 | 0.0889 |
8939 | FUBP3 | P9T-E | Human | Esophagus | ESCC | 3.52e-04 | 3.38e-02 | 0.1131 |
8939 | FUBP3 | P10T-E | Human | Esophagus | ESCC | 2.46e-19 | 2.85e-01 | 0.116 |
8939 | FUBP3 | P11T-E | Human | Esophagus | ESCC | 6.12e-05 | 2.54e-01 | 0.1426 |
8939 | FUBP3 | P12T-E | Human | Esophagus | ESCC | 1.01e-13 | 1.59e-01 | 0.1122 |
8939 | FUBP3 | P15T-E | Human | Esophagus | ESCC | 2.47e-10 | 2.33e-01 | 0.1149 |
8939 | FUBP3 | P16T-E | Human | Esophagus | ESCC | 5.95e-14 | 1.45e-01 | 0.1153 |
8939 | FUBP3 | P17T-E | Human | Esophagus | ESCC | 3.97e-03 | 1.30e-01 | 0.1278 |
8939 | FUBP3 | P20T-E | Human | Esophagus | ESCC | 1.48e-04 | 1.24e-02 | 0.1124 |
8939 | FUBP3 | P21T-E | Human | Esophagus | ESCC | 5.79e-19 | 2.52e-01 | 0.1617 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FUBP3 | SNV | Missense_Mutation | c.647N>T | p.Gly216Val | p.G216V | Q96I24 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FUBP3 | SNV | Missense_Mutation | c.256G>A | p.Asp86Asn | p.D86N | Q96I24 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FUBP3 | SNV | Missense_Mutation | novel | c.469N>T | p.Asp157Tyr | p.D157Y | Q96I24 | protein_coding | deleterious(0.02) | probably_damaging(0.935) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
FUBP3 | SNV | Missense_Mutation | novel | c.92N>G | p.Ala31Gly | p.A31G | Q96I24 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
FUBP3 | deletion | Frame_Shift_Del | c.1184delC | p.Pro395LeufsTer27 | p.P395Lfs*27 | Q96I24 | protein_coding | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |||
FUBP3 | SNV | Missense_Mutation | c.146C>T | p.Ser49Leu | p.S49L | Q96I24 | protein_coding | tolerated(0.08) | benign(0.319) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FUBP3 | SNV | Missense_Mutation | novel | c.742N>G | p.Asn248Asp | p.N248D | Q96I24 | protein_coding | tolerated(0.08) | benign(0) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FUBP3 | SNV | Missense_Mutation | c.190N>T | p.Val64Leu | p.V64L | Q96I24 | protein_coding | tolerated(0.52) | benign(0.031) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FUBP3 | SNV | Missense_Mutation | c.887G>T | p.Ser296Ile | p.S296I | Q96I24 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FUBP3 | SNV | Missense_Mutation | c.572G>A | p.Arg191Gln | p.R191Q | Q96I24 | protein_coding | tolerated(0.11) | probably_damaging(0.994) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |