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Gene: FTSJ1 |
Gene summary for FTSJ1 |
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Gene information | Species | Human | Gene symbol | FTSJ1 | Gene ID | 24140 |
Gene name | FtsJ RNA 2'-O-methyltransferase 1 | |
Gene Alias | CDLIV | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B7Z4K4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
24140 | FTSJ1 | LZE4T | Human | Esophagus | ESCC | 1.67e-12 | 4.09e-01 | 0.0811 |
24140 | FTSJ1 | LZE8T | Human | Esophagus | ESCC | 2.06e-05 | 2.29e-01 | 0.067 |
24140 | FTSJ1 | LZE20T | Human | Esophagus | ESCC | 6.85e-06 | 2.24e-01 | 0.0662 |
24140 | FTSJ1 | LZE22T | Human | Esophagus | ESCC | 3.93e-02 | 2.91e-01 | 0.068 |
24140 | FTSJ1 | LZE24T | Human | Esophagus | ESCC | 3.06e-07 | 2.93e-01 | 0.0596 |
24140 | FTSJ1 | LZE21T | Human | Esophagus | ESCC | 4.95e-04 | 3.31e-01 | 0.0655 |
24140 | FTSJ1 | LZE6T | Human | Esophagus | ESCC | 2.34e-03 | 2.85e-01 | 0.0845 |
24140 | FTSJ1 | P2T-E | Human | Esophagus | ESCC | 3.80e-27 | 4.42e-01 | 0.1177 |
24140 | FTSJ1 | P4T-E | Human | Esophagus | ESCC | 3.83e-26 | 5.46e-01 | 0.1323 |
24140 | FTSJ1 | P5T-E | Human | Esophagus | ESCC | 1.64e-24 | 6.76e-01 | 0.1327 |
24140 | FTSJ1 | P8T-E | Human | Esophagus | ESCC | 1.80e-27 | 6.44e-01 | 0.0889 |
24140 | FTSJ1 | P9T-E | Human | Esophagus | ESCC | 2.02e-18 | 4.39e-01 | 0.1131 |
24140 | FTSJ1 | P10T-E | Human | Esophagus | ESCC | 6.65e-24 | 3.69e-01 | 0.116 |
24140 | FTSJ1 | P11T-E | Human | Esophagus | ESCC | 3.09e-15 | 8.32e-01 | 0.1426 |
24140 | FTSJ1 | P12T-E | Human | Esophagus | ESCC | 1.61e-26 | 3.57e-01 | 0.1122 |
24140 | FTSJ1 | P15T-E | Human | Esophagus | ESCC | 5.01e-13 | 3.78e-01 | 0.1149 |
24140 | FTSJ1 | P16T-E | Human | Esophagus | ESCC | 3.58e-31 | 5.45e-01 | 0.1153 |
24140 | FTSJ1 | P17T-E | Human | Esophagus | ESCC | 6.92e-11 | 5.94e-01 | 0.1278 |
24140 | FTSJ1 | P19T-E | Human | Esophagus | ESCC | 1.27e-07 | 7.59e-01 | 0.1662 |
24140 | FTSJ1 | P20T-E | Human | Esophagus | ESCC | 2.73e-18 | 4.05e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:000218122 | Liver | HCC | cytoplasmic translation | 132/7958 | 148/18723 | 9.09e-33 | 5.76e-30 | 132 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FTSJ1 | SNV | Missense_Mutation | c.23A>C | p.Lys8Thr | p.K8T | Q9UET6 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FTSJ1 | SNV | Missense_Mutation | c.742N>T | p.Arg248Cys | p.R248C | Q9UET6 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
FTSJ1 | SNV | Missense_Mutation | c.742N>T | p.Arg248Cys | p.R248C | Q9UET6 | protein_coding | tolerated(0.11) | benign(0.006) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FTSJ1 | SNV | Missense_Mutation | rs782303332 | c.769N>A | p.Gly257Ser | p.G257S | Q9UET6 | protein_coding | tolerated(0.4) | benign(0.009) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD |
FTSJ1 | SNV | Missense_Mutation | c.566N>C | p.Ser189Thr | p.S189T | Q9UET6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FTSJ1 | SNV | Missense_Mutation | c.536G>A | p.Cys179Tyr | p.C179Y | Q9UET6 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FTSJ1 | SNV | Missense_Mutation | rs148812911 | c.190N>A | p.Gly64Arg | p.G64R | Q9UET6 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FTSJ1 | SNV | Missense_Mutation | novel | c.464C>T | p.Ala155Val | p.A155V | Q9UET6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FTSJ1 | SNV | Missense_Mutation | novel | c.539C>T | p.Ala180Val | p.A180V | Q9UET6 | protein_coding | tolerated(0.12) | benign(0.124) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FTSJ1 | SNV | Missense_Mutation | novel | c.851G>A | p.Gly284Glu | p.G284E | Q9UET6 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AJ-A3BF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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