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Gene: FAM173A |
Gene summary for FAM173A |
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Gene information | Species | Human | Gene symbol | FAM173A | Gene ID | 65990 |
Gene name | adenine nucleotide translocase lysine methyltransferase | |
Gene Alias | ANT-KMT | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | J3KMW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65990 | FAM173A | GSM4909282 | Human | Breast | IDC | 4.34e-02 | -1.55e-01 | -0.0288 |
65990 | FAM173A | GSM4909285 | Human | Breast | IDC | 4.88e-05 | -1.98e-01 | 0.21 |
65990 | FAM173A | GSM4909293 | Human | Breast | IDC | 2.41e-06 | 3.97e-01 | 0.1581 |
65990 | FAM173A | GSM4909296 | Human | Breast | IDC | 1.85e-07 | -7.83e-02 | 0.1524 |
65990 | FAM173A | GSM4909297 | Human | Breast | IDC | 1.77e-06 | 1.99e-02 | 0.1517 |
65990 | FAM173A | GSM4909298 | Human | Breast | IDC | 1.37e-05 | 3.23e-01 | 0.1551 |
65990 | FAM173A | GSM4909302 | Human | Breast | IDC | 2.01e-05 | 3.25e-01 | 0.1545 |
65990 | FAM173A | GSM4909304 | Human | Breast | IDC | 6.63e-14 | 5.04e-01 | 0.1636 |
65990 | FAM173A | GSM4909306 | Human | Breast | IDC | 6.17e-32 | 7.80e-01 | 0.1564 |
65990 | FAM173A | GSM4909308 | Human | Breast | IDC | 3.56e-19 | 5.06e-01 | 0.158 |
65990 | FAM173A | GSM4909311 | Human | Breast | IDC | 2.34e-14 | -1.59e-01 | 0.1534 |
65990 | FAM173A | GSM4909312 | Human | Breast | IDC | 3.46e-04 | -5.69e-02 | 0.1552 |
65990 | FAM173A | GSM4909313 | Human | Breast | IDC | 7.32e-07 | 2.93e-01 | 0.0391 |
65990 | FAM173A | GSM4909317 | Human | Breast | IDC | 2.59e-06 | 3.21e-01 | 0.1355 |
65990 | FAM173A | GSM4909318 | Human | Breast | IDC | 5.28e-03 | 3.36e-01 | 0.2031 |
65990 | FAM173A | GSM4909319 | Human | Breast | IDC | 2.38e-26 | 1.86e-01 | 0.1563 |
65990 | FAM173A | GSM4909320 | Human | Breast | IDC | 6.92e-17 | 6.30e-01 | 0.1575 |
65990 | FAM173A | GSM4909321 | Human | Breast | IDC | 9.47e-12 | 2.27e-01 | 0.1559 |
65990 | FAM173A | brca2 | Human | Breast | Precancer | 5.16e-04 | 1.54e-01 | -0.024 |
65990 | FAM173A | brca3 | Human | Breast | Precancer | 9.77e-04 | 8.87e-02 | -0.0263 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM173A | SNV | Missense_Mutation | novel | c.705C>A | p.Ser235Arg | p.S235R | Q9BQD7 | protein_coding | tolerated_low_confidence(0.05) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM173A | SNV | Missense_Mutation | rs370792065 | c.658N>A | p.Gly220Arg | p.G220R | Q9BQD7 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM173A | SNV | Missense_Mutation | novel | c.476N>G | p.Asp159Gly | p.D159G | Q9BQD7 | protein_coding | tolerated(0.13) | benign(0) | TCGA-56-7579-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
FAM173A | SNV | Missense_Mutation | rs201512651 | c.598N>T | p.Pro200Ser | p.P200S | Q9BQD7 | protein_coding | tolerated(0.44) | benign(0.038) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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