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Gene: FAM153C |
Gene summary for FAM153C |
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Gene information | Species | Human | Gene symbol | FAM153C | Gene ID | 653316 |
Gene name | protein FAM153C | |
Gene Alias | FAM153C | |
Cytomap | 5q35.3 | |
Gene Type | pseudo | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
653316 | FAM153C | HCC1 | Human | Liver | HCC | 5.16e-13 | 1.20e+00 | 0.5336 |
653316 | FAM153C | HCC2 | Human | Liver | HCC | 7.21e-18 | 7.93e-01 | 0.5341 |
653316 | FAM153C | HCC5 | Human | Liver | HCC | 2.21e-11 | 6.92e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM153C | SNV | Missense_Mutation | novel | c.118N>A | p.Gly40Arg | p.G40R | Q494X1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.976) | TCGA-GM-A4E0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
FAM153C | SNV | Missense_Mutation | novel | c.105G>T | p.Met35Ile | p.M35I | Q494X1 | protein_coding | tolerated_low_confidence(0.12) | benign(0.003) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD |
FAM153C | SNV | Missense_Mutation | novel | c.201C>G | p.His67Gln | p.H67Q | Q494X1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.643) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
FAM153C | SNV | Missense_Mutation | novel | c.223N>G | p.Thr75Ala | p.T75A | Q494X1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.953) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM153C | SNV | Missense_Mutation | novel | c.322N>G | p.Thr108Ala | p.T108A | Q494X1 | protein_coding | deleterious_low_confidence(0) | benign(0.388) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM153C | insertion | Frame_Shift_Ins | novel | c.104dupT | p.Met35IlefsTer12 | p.M35Ifs*12 | Q494X1 | protein_coding | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | ||
FAM153C | SNV | Missense_Mutation | novel | c.104N>A | p.Met35Lys | p.M35K | Q494X1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.027) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM153C | SNV | Missense_Mutation | c.164N>T | p.Pro55Leu | p.P55L | Q494X1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-49-4487-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM153C | SNV | Missense_Mutation | rs770475676 | c.295N>A | p.Ala99Thr | p.A99T | Q494X1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.682) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM153C | SNV | Missense_Mutation | novel | c.175N>T | p.Val59Phe | p.V59F | Q494X1 | protein_coding | deleterious_low_confidence(0.04) | benign(0.157) | TCGA-R5-A7O7-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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