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Gene: DYNC2I1 |
Gene summary for DYNC2I1 |
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Gene information | Species | Human | Gene symbol | DYNC2I1 | Gene ID | 55112 |
Gene name | dynein 2 intermediate chain 1 | |
Gene Alias | CFAP163 | |
Cytomap | 7q36.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A140VK66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55112 | DYNC2I1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.84e-06 | 1.49e-01 | 0.0155 |
55112 | DYNC2I1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-13 | 3.56e-01 | -0.1808 |
55112 | DYNC2I1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-12 | 4.02e-01 | -0.0811 |
55112 | DYNC2I1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.71e-24 | 4.91e-01 | -0.1088 |
55112 | DYNC2I1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.81e-29 | 5.47e-01 | -0.1954 |
55112 | DYNC2I1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 7.18e-01 | -0.2602 |
55112 | DYNC2I1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.67e-01 | -0.2196 |
55112 | DYNC2I1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.57e-06 | 1.91e-01 | -0.1207 |
55112 | DYNC2I1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 2.84e-01 | -0.1526 |
55112 | DYNC2I1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.19e-18 | 3.98e-01 | -0.1464 |
55112 | DYNC2I1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.89e-27 | 4.82e-01 | -0.1001 |
55112 | DYNC2I1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.00e-13 | 3.26e-01 | -0.059 |
55112 | DYNC2I1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.39e-01 | -0.1706 |
55112 | DYNC2I1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-04 | 2.52e-01 | -0.1462 |
55112 | DYNC2I1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.43e-09 | 3.04e-01 | -0.0842 |
55112 | DYNC2I1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.78e-05 | 4.03e-01 | -0.00410000000000005 |
55112 | DYNC2I1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.28e-08 | 2.00e-01 | 0.096 |
55112 | DYNC2I1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.08e-01 | 0.0446 |
55112 | DYNC2I1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.81e-03 | 2.70e-01 | 0.0451 |
55112 | DYNC2I1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.50e-08 | 4.03e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00307051 | Colorectum | SER | cytoskeleton-dependent intracellular transport | 44/2897 | 195/18723 | 5.53e-03 | 4.09e-02 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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