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Gene: DOPEY2 |
Gene summary for DOPEY2 |
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Gene information | Species | Human | Gene symbol | DOPEY2 | Gene ID | 9980 |
Gene name | DOP1 leucine zipper like protein B | |
Gene Alias | 21orf5 | |
Cytomap | 21q22.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y3R5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9980 | DOPEY2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.70e-31 | -7.05e-01 | 0.0155 |
9980 | DOPEY2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.43e-18 | -7.05e-01 | -0.1808 |
9980 | DOPEY2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.46e-04 | -7.05e-01 | 0.0216 |
9980 | DOPEY2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.22e-14 | -7.05e-01 | -0.0811 |
9980 | DOPEY2 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.33e-22 | -7.05e-01 | -0.1088 |
9980 | DOPEY2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.88e-33 | -7.05e-01 | -0.1954 |
9980 | DOPEY2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.70e-02 | -7.05e-01 | -0.2602 |
9980 | DOPEY2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.65e-03 | -7.05e-01 | -0.2196 |
9980 | DOPEY2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.41e-15 | -7.05e-01 | -0.1207 |
9980 | DOPEY2 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.06e-12 | -7.05e-01 | -0.1526 |
9980 | DOPEY2 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.45e-42 | -7.05e-01 | -0.1464 |
9980 | DOPEY2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.22e-41 | -7.05e-01 | -0.1001 |
9980 | DOPEY2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.66e-25 | -7.05e-01 | -0.059 |
9980 | DOPEY2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.64e-05 | -7.05e-01 | -0.1706 |
9980 | DOPEY2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.77e-06 | -7.05e-01 | -0.2061 |
9980 | DOPEY2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.46e-04 | -7.05e-01 | -0.1462 |
9980 | DOPEY2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.70e-10 | -7.05e-01 | -0.0842 |
9980 | DOPEY2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.70e-02 | -7.05e-01 | -0.00410000000000005 |
9980 | DOPEY2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.37e-08 | -7.05e-01 | -0.0179 |
9980 | DOPEY2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-27 | -7.05e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY2 | SNV | Missense_Mutation | novel | c.6487C>A | p.Pro2163Thr | p.P2163T | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.5416C>G | p.Leu1806Val | p.L1806V | Q9Y3R5 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.4835N>G | p.Asn1612Ser | p.N1612S | Q9Y3R5 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | c.5017N>G | p.Leu1673Val | p.L1673V | Q9Y3R5 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.262N>C | p.Glu88Gln | p.E88Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.6664N>A | p.Glu2222Lys | p.E2222K | Q9Y3R5 | protein_coding | tolerated(0.57) | benign(0.033) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | novel | c.404C>A | p.Pro135Gln | p.P135Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
DOPEY2 | insertion | Nonsense_Mutation | novel | c.6452_6453insCATTTGATAATACTTACTAGTTTTTTAT | p.Ala2152IlefsTer2 | p.A2152Ifs*2 | Q9Y3R5 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | Nonsense_Mutation | novel | c.4966_4967insCGCAAATGCATATGCAAATGCATGTATATAATTAAC | p.Gly1656delinsAlaGlnMetHisMetGlnMetHisValTyrAsnTerArg | p.G1656delinsAQMHMQMHVYN*R | Q9Y3R5 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | In_Frame_Ins | novel | c.2865_2866insACTCTGGTTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAATAAA | p.Arg955_Ser956insThrLeuValTrpValThrGluGlnAspSerValSerLysAsnLys | p.R955_S956insTLVWVTEQDSVSKNK | Q9Y3R5 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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