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Gene: DARS |
Gene summary for DARS |
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Gene information | Species | Human | Gene symbol | DARS | Gene ID | 1615 |
Gene name | aspartyl-tRNA synthetase 1 | |
Gene Alias | DARS | |
Cytomap | 2q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | P14868 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1615 | DARS | CCI_1 | Human | Cervix | CC | 2.30e-07 | 4.41e-01 | 0.528 |
1615 | DARS | CCI_2 | Human | Cervix | CC | 1.84e-19 | 7.33e-01 | 0.5249 |
1615 | DARS | CCI_3 | Human | Cervix | CC | 3.66e-13 | 5.03e-01 | 0.516 |
1615 | DARS | Tumor | Human | Cervix | CC | 8.06e-30 | 4.81e-01 | 0.1241 |
1615 | DARS | sample1 | Human | Cervix | CC | 7.99e-12 | 3.35e-01 | 0.0959 |
1615 | DARS | sample3 | Human | Cervix | CC | 4.67e-35 | 4.74e-01 | 0.1387 |
1615 | DARS | H2 | Human | Cervix | HSIL_HPV | 4.50e-17 | 3.18e-01 | 0.0632 |
1615 | DARS | L1 | Human | Cervix | CC | 2.90e-02 | 1.62e-01 | 0.0802 |
1615 | DARS | T1 | Human | Cervix | CC | 3.91e-16 | 3.12e-01 | 0.0918 |
1615 | DARS | T2 | Human | Cervix | CC | 8.06e-10 | 3.81e-01 | 0.0709 |
1615 | DARS | T3 | Human | Cervix | CC | 3.25e-30 | 4.53e-01 | 0.1389 |
1615 | DARS | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.58e-28 | -5.90e-01 | 0.0155 |
1615 | DARS | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.18e-16 | -5.90e-01 | -0.1808 |
1615 | DARS | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.69e-03 | -5.90e-01 | 0.0216 |
1615 | DARS | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.14e-12 | -5.90e-01 | -0.0811 |
1615 | DARS | HTA11_78_2000001011 | Human | Colorectum | AD | 1.42e-19 | -5.90e-01 | -0.1088 |
1615 | DARS | HTA11_347_2000001011 | Human | Colorectum | AD | 6.30e-30 | -5.90e-01 | -0.1954 |
1615 | DARS | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.01e-03 | -5.90e-01 | -0.2196 |
1615 | DARS | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.70e-13 | -5.90e-01 | -0.1207 |
1615 | DARS | HTA11_83_2000001011 | Human | Colorectum | SER | 1.58e-10 | -5.90e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Esophagus | ESCC | ![]() |
Skin | AK | ![]() |
Skin | SCCIS | ![]() |
Skin | cSCC | ![]() |
Thyroid | HT | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00064181 | Colorectum | SER | tRNA aminoacylation for protein translation | 17/2897 | 41/18723 | 5.75e-05 | 1.35e-03 | 17 |
GO:00430391 | Colorectum | SER | tRNA aminoacylation | 17/2897 | 44/18723 | 1.64e-04 | 3.12e-03 | 17 |
GO:00430381 | Colorectum | SER | amino acid activation | 17/2897 | 45/18723 | 2.25e-04 | 3.91e-03 | 17 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0000959 | Liver | HCC | mitochondrial RNA metabolic process | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DARS | SNV | Missense_Mutation | c.406N>C | p.Glu136Gln | p.E136Q | P14868 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DARS | SNV | Missense_Mutation | c.396G>T | p.Gln132His | p.Q132H | P14868 | protein_coding | tolerated(0.24) | probably_damaging(0.93) | TCGA-E2-A1AZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DARS | SNV | Missense_Mutation | c.238C>A | p.Leu80Ile | p.L80I | P14868 | protein_coding | tolerated(0.07) | benign(0.107) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DARS | SNV | Missense_Mutation | c.1296A>G | p.Ile432Met | p.I432M | P14868 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DARS | SNV | Missense_Mutation | novel | c.1016N>G | p.Phe339Cys | p.F339C | P14868 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DARS | SNV | Missense_Mutation | novel | c.857N>A | p.Phe286Tyr | p.F286Y | P14868 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DARS | SNV | Missense_Mutation | novel | c.811N>A | p.Val271Ile | p.V271I | P14868 | protein_coding | deleterious(0.01) | possibly_damaging(0.885) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DARS | SNV | Missense_Mutation | rs761143098 | c.1013N>C | p.Lys338Thr | p.K338T | P14868 | protein_coding | tolerated(0.09) | benign(0.103) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DARS | SNV | Missense_Mutation | rs756729890 | c.901N>A | p.Glu301Lys | p.E301K | P14868 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DARS | SNV | Missense_Mutation | rs779248283 | c.1249N>A | p.Asp417Asn | p.D417N | P14868 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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